Molecular Advances and Views in Triple-Negative Breast Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 39
Special Issue Editor
Interests: breast cancer; hormone receptors; triple negative; HER-2/neu; pregnancy-associated breast cancer; gene mutations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Triple-negative breast cancer (TNBC) remains one of the most challenging subtypes of breast malignancies, accounting for approximately 15–20% of all breast cancers and disproportionately affecting younger women and certain ethnic groups. Characterized by the absence of estrogen receptor, progesterone receptor, and HER2 amplification, TNBC lacks the benefit of established targeted therapies, such as endocrine or HER2-directed treatment. Historically, cytotoxic chemotherapy has represented the cornerstone of management. However, recent molecular discoveries and translational advances are reshaping the therapeutic landscape.
Advances in genomic and transcriptomic profiling have highlighted the heterogeneity of TNBC. Subclassification into basal-like, mesenchymal, immunomodulatory, and luminal androgen receptor (LAR) subtypes has provided a molecular framework to understand differential biology and therapeutic vulnerabilities. This stratification not only guides biomarker discovery but also paves the way for approaches involving precision medicine.
For this Special Issue, we welcome original research articles and reviews.
Aim: The aim of this editorial is to highlight recent molecular insights into triple-negative breast cancer (TNBC), underscore how these advances are reshaping therapeutic strategies, and provide perspectives on future directions in research and clinical management.
Research areas may include (but are not limited to) the following: emerging therapeutic targets; biomarker development and precision oncology; and future perspectives.
We look forward to receiving your contributions.
Dr. Ioannis Boutas
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- breast cancer
- molecular biology
- personalized medicine
- triple-negative breast cancer
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
