Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
The Role of Immune System in Tissue Repair and Regeneration
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

The Role of Immune System in Tissue Repair and Regeneration

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 5378

Special Issue Editors

Dr. Annalisa Grimaldi

E-Mail
Guest Editor
Department of Biotechnology and Life Sciences, DBSV, University of Insubria, 21100 Varese, Italy
Interests: immunity; wound healing; angiogenesis and signaling pathways involved in innate immune response and regenerative processes in invertebrate animal model
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Giovanna Parisi

E-Mail
Guest Editor
Department of Biotechnology and Life Science, University of Insubria, Via Dunant 3, 21100 Varese, Italy
Interests: humoral and cell-mediated innate immune system; inflammatory response and regeneration process in coastal marine animals; isolation of secondary metabolites and bioactive molecules from marine invertebrates and fish; functional responses to anthropogenic and environmental stressors in systemic bio-monitoring
Special Issues, Collections and Topics in MDPI journals
Dr. Nicolò Baranzini

E-Mail
Guest Editor
Department of Biotechnology and Life Sciences, DBSV, University of Insubria, 21100 Varese, Italy
Interests: immunity; wound healing; angiogenesis and signaling pathways involved in innate immune response and regenerative processes in invertebrate animal model
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to contribute to this Special Issue of the International Journal of Molecular Sciences on “Immunity and Tissue Remodeling Research”.

Inflammation and innate immunity are highly conserved processes and are functionally linked to tissue repair and wound healing in both vertebrates and invertebrates. Moreover, recent discoveries have also suggested a crucial role of adaptive immunity in the regenerative capacity of vertebrates' limbs.

This Special Issue will bring together original research articles and reviews on cells, immunity-effector molecules, and mechanisms involved in regulating inflammation, innate and adaptive immunity, and tissue regeneration processes. New information and a better understanding of this field would be helpful to find new approaches for clinical application to decrease wound complications and obtain successful tissue regeneration.

Dr. Annalisa Grimaldi
Dr. Maria Giovanna Parisi
Dr. Nicolò Baranzini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunity
  • inflammation
  • tissue remodeling and regeneration
  • cellular activity
  • cytokines
  • PRRs
  • CDs
  • cell–ECM interactions
  • collagen
  • in vivo and in vitro studies

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

19 pages, 4576 KiB  
Article
Genetic Deficiency of the Long Pentraxin 3 Affects Osteogenesis and Osteoclastogenesis in Homeostatic and Inflammatory Conditions
by Valentina Granata, Dario Strina, Maria Lucia Schiavone, Barbara Bottazzi, Alberto Mantovani, Antonio Inforzato and Cristina Sobacchi
Int. J. Mol. Sci. 2023, 24(23), 16648; https://doi.org/10.3390/ijms242316648 - 23 Nov 2023
Cited by 1 | Viewed by 1497
Abstract
The long pentraxin 3 (PTX3) is a soluble glycoprotein made by immune and nonimmune cells endowed with pleiotropic functions in innate immunity, inflammation, and tissue remodeling. PTX3 has recently emerged as a mediator of bone turnover in both physiological and pathological conditions, with [...] Read more.
The long pentraxin 3 (PTX3) is a soluble glycoprotein made by immune and nonimmune cells endowed with pleiotropic functions in innate immunity, inflammation, and tissue remodeling. PTX3 has recently emerged as a mediator of bone turnover in both physiological and pathological conditions, with direct and indirect effects on osteoblasts and osteoclasts. This notwithstanding, its role in bone biology, with major regard to the osteogenic potential of osteoblasts and their interplay with osteoclasts, is at present unclear. Here, we investigated the contribution of this pentraxin to bone deposition in the osteogenic lineage by assessing collagen production, mineralization capacity, osteoblast maturation, extracellular matrix gene expression, and inflammatory mediators’ production in primary osteoblasts from the calvaria of wild-type (WT) and Ptx3-deficient (Ptx3−/−) mice. Also, we evaluated the effect of PTX3 on osteoclastogenesis in cocultures of primary osteoblasts and bone marrow-derived osteoclasts. Our investigations were carried out both in physiological and inflammatory conditions to recapitulate in vitro aspects of inflammatory diseases of the bone. We found that primary osteoblasts from WT animals constitutively expressed low levels of the protein in osteogenic noninflammatory conditions, and genetic ablation of PTX3 in these cells had no major impact on collagen and hydroxyapatite deposition. However, Ptx3−/− osteoblasts had an increased RANKL/OPG ratio and CD44 expression, which resulted in in enhanced osteoclastogenesis when cocultured with bone marrow monocytes. Inflammation (modelled through administration of tumor necrosis factor-α, TNF-α) boosted the expression and accumulation of PTX3 and inflammatory mediators in WT osteoblasts. In these conditions, Ptx3 genetic depletion was associated with reduced collagen deposition and immune modulators’ production. Our study shed light on the role of PTX3 in osteoblast and osteoclast biology and identified a major effect of inflammation on the bone-related properties of this pentraxin, which might be relevant for therapeutic and/or diagnostic purposes in musculoskeletal pathology. Full article
(This article belongs to the Special Issue The Role of Immune System in Tissue Repair and Regeneration)
►▼ Show Figures

Figure 1

16 pages, 4745 KiB  
Article
Step-by-Step Regeneration of Tentacles after Injury in Anemonia viridis—Morphological and Structural Cell Analyses
by Claudia La Corte, Nicolò Baranzini, Mariano Dara, Camilla Bon, Annalisa Grimaldi, Maria Giovanna Parisi, Maria Grazia Zizzo and Matteo Cammarata
Int. J. Mol. Sci. 2023, 24(10), 8860; https://doi.org/10.3390/ijms24108860 - 16 May 2023
Cited by 2 | Viewed by 2556
Abstract
Benthic marine invertebrates, such as corals, are often subjected to injury caused by several sources. Here, the differences and characteristics in injured and health tissues in terms of cellular components are shown through a histological investigation of the soft coral Anemonia viridis at [...] Read more.
Benthic marine invertebrates, such as corals, are often subjected to injury caused by several sources. Here, the differences and characteristics in injured and health tissues in terms of cellular components are shown through a histological investigation of the soft coral Anemonia viridis at 0 h, 6 h, 24 h, and 7 days after injury caused by tentacle amputation. In addition, a new tool was used for the first time in invertebrates, positron emission tomography, in order to investigate the events that occur during regeneration within a longer time period (0 h, 24 h, and 14 days after the tentacles were cut). Higher integrated density values were measured through a densitometric analysis in sections stained with Fontana–Masson at 24 h after the tentacles were cut. This suggests an increase in melanin-like containing cells and a subsequent increase in fibroblast-like cells differentiated by amoebocytes that converge to the lesion site in the early stages of inflammation and regeneration. This work provides, for the first time, an elucidation of the events that occur during wound-healing and regeneration in basal metazoan, focusing on the characterisation of immune cells and their role. Our results indicate that Mediterranean anthozoan proves to be a valuable model for studying regeneration. Many events highlighted in this research occur in different phyla, suggesting that they are highly conserved. Full article
(This article belongs to the Special Issue The Role of Immune System in Tissue Repair and Regeneration)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

22 pages, 1293 KiB  
Review
Thymus Degeneration in Women and the Influence of Female Sexual Hormones on Thymic Epithelial Cells
by Meiru Zhou, Yaoying Shu and Jianli Gao
Int. J. Mol. Sci. 2025, 26(7), 3014; https://doi.org/10.3390/ijms26073014 - 26 Mar 2025
Viewed by 211
Abstract
The thymus is a central immune organ for T cell development and plays an extremely important role in immune and aging. The unique physiological processes that occur in women, such as the menstrual cycle, pregnancy, and menopause, contribute to sexual dimorphism in thymic [...] Read more.
The thymus is a central immune organ for T cell development and plays an extremely important role in immune and aging. The unique physiological processes that occur in women, such as the menstrual cycle, pregnancy, and menopause, contribute to sexual dimorphism in thymic immunity. Thymic epithelial cells (TECs) are key stromal cells that affect thymus development and degeneration. Interestingly, TECs in women have stronger proliferation potentiality and ability for output of T cells than those in men. In comparison to men, women exhibit higher susceptibility to autoimmune disease, which can be attributed to lower AIRE expression in the female thymus, which is influenced by fluctuating hormone levels. In this review, we summarize the principles of female thymus regulation by hormones, particularly the influence of female sex hormones in the development and function of TECs, as well as the underlying mechanisms, with the aim of providing new ideas and strategies to inhibit or slow down female thymus degeneration. Full article
(This article belongs to the Special Issue The Role of Immune System in Tissue Repair and Regeneration)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop