Molecular Research on Apoptosis and Autophagy in Osteosarcoma
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 471
Special Issue Editors
Interests: molecular and cellular pathology; 5-hydroxytryptamine; differentiation; regeneration; bone; CNS
Special Issues, Collections and Topics in MDPI journals
Interests: stem cell; differentiation; regeneration; aging; cancer; bone
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Osteosarcoma is the most common malignant bone cancer. It originates from osteoblasts of mesenchymal origin that produce an immature osteoid matrix. Current treatment recommendations for osteosarcoma include neoadjuvant chemotherapy, surgical resection, and adjuvant chemotherapy. However, the five-year survival rate for patients has not significantly improved despite ongoing research efforts. A complex cascade of signaling pathways and mechanisms is involved in osteosarcoma. Despite the great heterogeneity of the various human tumor types, cancers share eight characteristics known as the “hallmarks of cancer”, including uncontrolled proliferation, resistance to apoptosis, evasion of growth suppression, induction and access to the vasculature, activation of invasion and metastasis, avoidance of immune destruction, and continuous proliferative signaling. Typically, the malignant transformation of normal cells and benign tumors evades apoptosis through an imbalance between programmed cell death and proliferation. Apoptosis is not the only type of programmed cell death that has been observed recently; autophagy and necroptosis, in particular, are being extensively researched in the field of cancer biology. Autophagy is a self-degradative process involving lysosomal degradation that regulates cell survival by removing and recycling cellular components. Necroptosis is a caspase-independent, fail-safe type of programmed cell death. Therefore, molecular research targeting apoptosis, autophagy, and new regulations may be a promising strategy for the prevention and treatment of cancers and their associated diseases. This Special Issue focuses on “Molecular Research on Apoptosis and Autophagy in Osteosarcoma” in vitro, ex vivo, and/or in vivo studies. We warmly welcome submissions, including original papers and reviews, on this widely discussed topic.
Prof. Dr. Hyung-Mun Yun
Dr. Kyung-Ran Park
Guest Editors
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Keywords
- apoptosis
- autophagy
- bioactive molecule
- cancer
- necroptosis
- osteosarcoma
- osteoclast
- osteoblast
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