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Association Between Oxidative Stress and Metabolic Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 564

Special Issue Editor

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to an upcoming Special Issue, titled "Association Between Oxidative Stress and Metabolic Diseases". This issue will focus on the growing body of research exploring the intricate relationship between oxidative stress and metabolic disorders, including but not limited to diabetes, obesity, and cardiovascular diseases.

Given your expertise, we would be honored to have you submit a manuscript for this Special Issue. We believe that your research would be a valuable addition to this discussion and are confident that your contribution would offer important insights into this critical field of study.

This Special Issue will cover a wide range of topics, including the following:

  • Mechanisms linking oxidative stress to metabolic diseases;
  • Therapeutic strategies targeting oxidative stress in metabolic disorders;
  • Novel biomarkers and diagnostic tools related to oxidative stress;
  • The role of antioxidants in managing metabolic/endocrine diseases;
  • Oxidative stress and endocrine disorders.

If you are interested in contributing, we kindly ask you to submit a brief abstract (approximately 300 words) outlining your proposed contribution.

We look forward to the possibility of your participation and hope that you will consider contributing to this important collection of IJMS.

Kind regards,

Dr. Andrea Silvestrini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic disease
  • oxidative stress
  • low-grade inflammation
  • antioxidant
  • endocrine disease
  • radical species

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Published Papers (1 paper)

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Research

10 pages, 1946 KiB  
Article
Effect of Vitamin E on Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats
by David Segura Cobos, Esperanza Enedina Díaz Salgado, Dante Amato, Sinaí Ernesto Cardoso García, Tomás Ernesto Villamar Duque, Anayantzin Paulina Heredia Antúnez, Leonardo del Valle Mondragón, Gil Alfonso Magos Guerrero and Elizabeth Alejandrina Guzmán Hernández
Int. J. Mol. Sci. 2025, 26(4), 1597; https://doi.org/10.3390/ijms26041597 - 13 Feb 2025
Viewed by 416
Abstract
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus; oxidative stress plays a key role in the pathogenesis of DN. The objective of this study was to evaluate the antioxidant effect of vitamin E on diabetic nephropathy. A control group and three [...] Read more.
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus; oxidative stress plays a key role in the pathogenesis of DN. The objective of this study was to evaluate the antioxidant effect of vitamin E on diabetic nephropathy. A control group and three groups of rats with streptozotocin-induced diabetes mellitus (untreated diabetic rats and diabetic rats treated with vitamin E 250 and 500 mg/kg) were studied. After 4 weeks of treatment, the kidneys were removed under anesthesia with sodium pentobarbital. The kidneys were weighed, the AT1 and AT2 receptor expression was measured by Western blot, and the activities of glutathione peroxidase, catalase, and superoxide dismutase were determined in the renal cortex. Rats with diabetes mellitus had hyperglycemia, increased food and water consumption, and higher urinary volume than control rats. In diabetic rats (DM), kidney hypertrophy was observed and measured by kidney weight, protein/DNA ratio in the renal cortex, and proximal tubular cell area; proteinuria and reduced creatinine clearance were observed. AT1 and AT2 receptor expression in the kidney cortex of DM rats increased significantly compared to normoglycemic rats; antioxidant enzyme activities were decreased; treatment with vitamin E reversed kidney hypertrophy and reduced proteinuria; reduction in expression of AT1 and AT2 receptors was associated with increased antioxidant activity. Thus, treatment with vitamin E slows the progress of DN. Full article
(This article belongs to the Special Issue Association Between Oxidative Stress and Metabolic Diseases)
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