Molecular Researches on Ischemic Stroke—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 2374
Special Issue Editor
Interests: stroke; extrapiramidal syndromes; sex differences in neurological disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Stroke has become a serious issue for health systems in addition to being a major cause of death and long-term adult disability worldwide; in order to establish effective treatments, understanding the wide range of molecular pathways leading to neuronal death or enhancing damage is one of the important goals in stroke research. Critical points for stroke physiopathology are local hypoxia that damages brain tissue and neuronal death. Reperfusion therapies, the only available treatments for ischemic stroke, only work directly on the first mechanism, decreasing neuronal death via the quick recovery of blood flow in a therapeutic time window. Reperfusion treatments outside of a therapeutic time window can result in a hemorrhagic transformation. Many mechanisms are involved independently or in combination in stroke neuronal death, including excitotoxicity, mitochondrial death pathways, the release of free radicals, protein misfolding, apoptosis, necrosis, autophagy, and inflammation. The loss of astrocytes, as well as injury to white matter, may play a crucial role in stroke physiopathology. Potential drugs for stroke are agents that could provide the inhibition of cell death pathways.
This Special Issue of the International Journal of Molecular Sciences aims to provide new avenues into molecular research on ischemic stroke. A better knowledge of the molecular pathways involved may be useful to develop new effective treatments without the limitation of reperfusion therapy (time window, hemorrhagic transformation) for stroke, or new ones that work in synergy with standard therapy. Submissions highlighting each of these topics are welcome. Clinical and basic science contributions, consisting of original papers or reviews, will be equally considered.
Dr. Valentina Arnao
Guest Editor
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Keywords
- ischemic stroke
- molecular pathway
- brain damage and neuronal death
- excitotoxicity and apoptosis
- inflammation
- autophagy
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