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Zebrafish Model for Toxicological and Pharmacological Research
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Zebrafish Model for Toxicological and Pharmacological Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 2843

Special Issue Editor

Dr. Luca Del Giacco

E-Mail Website
Guest Editor
Dipartimento di Bioscienze, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy
Interests: zebrafish; neurodevelopment/neurodegeneration (Parkinson’s disease, amyotrophic lateral sclerosis); ear development/hearing loss; ciliogenesis and ciliopathies; acute myeloid leukemia; zebrafish embryo xenografts; ecotoxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The zebrafish (Danio rerio) has long been used as a model species for developmental biology studies. Zebrafish, however, offer considerably more as a model species and are now involved in many different research fields including, toxicology, neurobiology, immunology, and cancer, just to name a few. In addition, the employment of zebrafish embryos has enormously facilitated different sort of chemical testing, from pollutants toxicity assay to high-throughput drug screening. The relevant genetic homology with humans, the applicability of genome editing and transgenesis technologies, together with easy and low-cost protocols to expose the embryos to different compounds, make zebrafish a powerful tool for modeling human diseases and better understanding cellular and molecular mechanisms of toxicants and new therapeutics. Indeed, the potential of zebrafish is becoming increasingly evident, and the availability of these models allows for an increased understanding of the role of chemical exposure in human disease. In this Special Issue, we welcome contributions that show recent developments in zebrafish as a model for toxicological research and drug discovery, as well as new insights on the effects of chemical exposure in zebrafish models of human diseases. Translational studies that employ molecular methods to enhance our understanding of human health or environmental risk are also of interest.

Dr. Luca Del Giacco
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular toxicology
  • pharmacology
  • toxicity testing
  • zebrafish
  • disease genetics
  • molecular mechanisms
  • high throughput screening

Published Papers (2 papers)

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Research

17 pages, 4357 KiB  
Article
Biocompatibility Analysis of Bio-Based and Synthetic Silica Nanoparticles during Early Zebrafish Development
by Cinzia Bragato, Roberta Mazzotta, Andrea Persico, Rossella Bengalli, Mariana Ornelas, Filipa Gomes, Patrizia Bonfanti and Paride Mantecca
Int. J. Mol. Sci. 2024, 25(10), 5530; https://doi.org/10.3390/ijms25105530 - 18 May 2024
Viewed by 368
Abstract
During the twenty-first century, engineered nanomaterials (ENMs) have attracted rising interest, globally revolutionizing all industrial sectors. The expanding world population and the implementation of new global policies are increasingly pushing society toward a bioeconomy, focused on fostering the adoption of bio-based nanomaterials that [...] Read more.
During the twenty-first century, engineered nanomaterials (ENMs) have attracted rising interest, globally revolutionizing all industrial sectors. The expanding world population and the implementation of new global policies are increasingly pushing society toward a bioeconomy, focused on fostering the adoption of bio-based nanomaterials that are functional, cost-effective, and potentially secure to be implied in different areas, the medical field included. This research was focused on silica nanoparticles (SiO2-NPs) of bio-based and synthetic origin. SiO2-NPs are composed of silicon dioxide, the most abundant compound on Earth. Due to their characteristics and biocompatibility, they are widely used in many applications, including the food industry, synthetic processes, medical diagnosis, and drug delivery. Using zebrafish embryos as in vivo models, we evaluated the effects of amorphous silica bio-based NPs from rice husk (SiO2-RHSK NPs) compared to commercial hydrophilic fumed silica NPs (SiO2-Aerosil200). We evaluated the outcomes of embryo exposure to both nanoparticles (NPs) at the histochemical and molecular levels to assess their safety profile, including developmental toxicity, neurotoxicity, and pro-inflammatory potential. The results showed differences between the two silica NPs, highlighting that bio-based SiO2-RHSK NPs do not significantly affect neutrophils, macrophages, or other innate immune system cells. Full article
(This article belongs to the Special Issue Zebrafish Model for Toxicological and Pharmacological Research)
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16 pages, 6125 KiB  
Article
Effects of Single and Combined Ciprofloxacin and Lead Treatments on Zebrafish Behavior, Oxidative Stress, and Elements Content
by Roxana Jijie, Emanuela Paduraru, Ira-Adeline Simionov, Caterina Faggio, Alin Ciobica and Mircea Nicoara
Int. J. Mol. Sci. 2023, 24(5), 4952; https://doi.org/10.3390/ijms24054952 - 3 Mar 2023
Cited by 6 | Viewed by 1963
Abstract
Even though the toxic effects of antibiotics and heavy metals have been extensively studied in the last decades, their combined adverse impact on aquatic organisms is poorly understood. Therefore, the objective of this study was to assess the acute effects of a ciprofloxacin [...] Read more.
Even though the toxic effects of antibiotics and heavy metals have been extensively studied in the last decades, their combined adverse impact on aquatic organisms is poorly understood. Therefore, the objective of this study was to assess the acute effects of a ciprofloxacin (Cipro) and lead (Pb) mixture on the 3D swimming behavior, acetylcholinesterase (AChE) activity, lipid peroxidation level (MDA—malondialdehyde), activity of some oxidative stress markers (SOD—superoxide dismutase and GPx—glutathione peroxidase), and the essential elements content (Cu—copper, Zn—zinc, Fe—iron, Ca—calcium, Mg—magnesium, Na—sodium and K—potassium) in the body of zebrafish (Danio rerio). For this purpose, zebrafish were exposed to environmentally relevant concentrations of Cipro, Pb, and a mixture for 96 h. The results revealed that acute exposure to Pb alone and in mixture with Cipro impaired zebrafish exploratory behavior by decreasing swimming activity and elevating freezing duration. Moreover, significant deficiencies of Ca, K, Mg, and Na contents, as well as an excess of Zn level, were observed in fish tissues after exposure to the binary mixture. Likewise, the combined treatment with Pb and Cipro inhibited the activity of AChE and increased the GPx activity and MDA level. The mixture produced more damage in all studied endpoints, while Cipro had no significant effect. The findings highlight that the simultaneous presence of antibiotics and heavy metals in the environment can pose a threat to the health of living organisms. Full article
(This article belongs to the Special Issue Zebrafish Model for Toxicological and Pharmacological Research)
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