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Interconnecting Cytokine-Associated Molecular Pathways and Pathogenesis of Inflammatory Skin Diseases...
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Interconnecting Cytokine-Associated Molecular Pathways and Pathogenesis of Inflammatory Skin Diseases 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 12039

Special Issue Editors

Prof. Dr. Cristina Albanesi

E-Mail Website1 Website2
Guest Editor
Laboratory of Experimental Immunology, Fondazione Luigi Maria Monti—Istituto Dermopatico dell’Immacolata (IDI)-IRCCS, Via Monti di Creta, 104, 00167 Rome, Italy
Interests: skin immunology; skin pathology; inflammation; keratinocytes; cytokines; signal transduction; biologics; pharmacogenomics
Special Issues, Collections and Topics in MDPI journals
Dr. Stefania Madonna

E-Mail Website
Guest Editor
Laboratory of Experimental Immunology, Fondazione Luigi Maria Monti—Istituto Dermopatico dell’Immacolata (IDI)-IRCCS, Via Monti di Creta, 104, 00167 Rome, Italy
Interests: inflammatory chemokines; psoriasis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cytokines are key modulators of inflammation, participating in acute and chronic inflammation via a complex network of molecular interactions. Several diseases, including immune-mediated and inflammatory disorders involving the cutaneous district, depend on alterations of intracellular pathways relevant to cytokine signaling or cytokine production. In the past, the comprehension of how these pathways are regulated has permitted a more accurate identification of the pathogenic processes associated with skin diseases, as well as advances in pharmaceutical drug development targeting cytokines and related molecular pathways.

In the present Special Issue on “Interconnecting Cytokine-Associated Molecular Pathways and Pathogenesis of Inflammatory Skin Diseases 2.0”, we invite contributions addressing pathophysiological molecular mechanisms influenced by cytokines and involved in immune-mediated skin diseases with related co-morbidities. Studies may also address pathways targeted by current drugs that can block pathogenic cytokines, receptors, or their intracellular effectors in diseased skin.

Original research articles and reviews are equally welcome, and may involve studies in human skin diseases, as well as in vitro and in vivo studies in different skin cells and disease models.

Prof. Dr. Cristina Albanesi
Dr. Stefania Madonna
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cytokines
  • inflammation
  • skin diseases
  • signal transduction
  • interleukins
  • JAK-STAT
  • biologics
  • small molecules
  • psoriasis
  • atopic dermatitis

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Related Special Issue

Published Papers (5 papers)

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Research

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19 pages, 5178 KiB  
Article
Selected miRNA and Psoriasis—Cardiovascular Disease (CVD)—Overweight/Obesity Network—A Pilot Study
by Anna Michalak-Stoma, Katarzyna Walczak, Michał Adamczyk, Małgorzata Kowal and Dorota Krasowska
Int. J. Mol. Sci. 2023, 24(18), 13916; https://doi.org/10.3390/ijms241813916 - 10 Sep 2023
Cited by 1 | Viewed by 1382
Abstract
Psoriasis is nowadays recognized as a multifactorial systemic disease with complex and not fully understood pathogenesis. In psoriatic patients, the increased cardiovascular disease (CVD) risk and frequent comorbidities like obesity are observed. The aim of this study was to investigate differences in miRNA [...] Read more.
Psoriasis is nowadays recognized as a multifactorial systemic disease with complex and not fully understood pathogenesis. In psoriatic patients, the increased cardiovascular disease (CVD) risk and frequent comorbidities like obesity are observed. The aim of this study was to investigate differences in miRNA (miR-22-3p, miR-133a-3p, miR-146a-5p, miR-369-3p, and Let-7b-5p) involved in CVD risk among psoriatic patients with overweight/obesity and with normal weight. The study comprised 28 male psoriatic patients and 16 male healthy controls. miRNA isolated from peripheral blood mononuclear cells was reverse-transcribed and RT-qPCR was performed. We have found decreased levels of miR-22, miR-133a, miR-146a, and miR-369 among the psoriatic patients. There was a statistically significant difference in miR-22 and miR-146a levels between psoriatic patients with overweight/obesity and with normal weight. There were positive correlations between miR-22 and miR-146a levels and psoriatic arthritis (PsA) in psoriatic patients with normal weight and between the miR-133a level and PsA in the overweight/obese patients. The decreased levels of selected miRNA are consistent with the levels observed in CVD indicating their impact on the CVD risk in psoriatic patients. miR-22 and miR-146 may be recognized as one of the contributing factors in the obesity-CVD-psoriasis network. Full article
(This article belongs to the Special Issue Interconnecting Cytokine-Associated Molecular Pathways and Pathogenesis of Inflammatory Skin Diseases 2.0)
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12 pages, 2453 KiB  
Article
Torilis japonica Extract Suppresses the Induction of Atopic Inflammation
by Ji-Won Seo, Hyo-Jae Lee, Young-Mi Youk, Gun-He Nam and Young-Min Kim
Int. J. Mol. Sci. 2023, 24(3), 2102; https://doi.org/10.3390/ijms24032102 - 20 Jan 2023
Cited by 4 | Viewed by 1576
Abstract
As one of the major intractable allergic disorders, atopic inflammation is commonly accompanied by itching, dry skin, and inflammation. Atopic inflammation deteriorates the quality of life and has no fundamental cure, so it is crucial to urgently explore and develop natural resources for [...] Read more.
As one of the major intractable allergic disorders, atopic inflammation is commonly accompanied by itching, dry skin, and inflammation. Atopic inflammation deteriorates the quality of life and has no fundamental cure, so it is crucial to urgently explore and develop natural resources for long-term treatment without any side effects. This study aimed to verify Torilis japonica extract (TJE)’s relieving effect and mechanism against atopic inflammation using skin cells and skin equivalent models, as well as to investigate torilin’s effect (obtained from TJE) and other unknown components as marker compounds. Torilin concentration was verified in TJE using high-performance liquid chromatography and analyzed the unknown components using nuclear magnetic resonance spectroscopy. Furthermore, TJE’s cytotoxicity, regenerative effect, and cell cycle regulation effects were confirmed using skin cells with atopic inflammation (human dermal fibroblasts and HaCaT keratinocytes) by using TNF-α and IFN-γ treatments. Consequently, TJE was demonstrated to regulate TARC and CTACK expressions as chemokines and those of interleukin-4, -5, and -13 as cytokines related to atopic inflammation. TJE was further confirmed to affect the matrix metalloproteinase-1, -2, and -9 expressions, which are essential in skin damage. Lastly, this study confirmed TJE’s relieving effect against atopic inflammation through a 3D skin model and RhCE model using human dermal fibroblasts and HaCaT keratinocytes. These findings on atopic inflammation verified torilin’s relieving effects and TJE’s other components. Full article
(This article belongs to the Special Issue Interconnecting Cytokine-Associated Molecular Pathways and Pathogenesis of Inflammatory Skin Diseases 2.0)
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14 pages, 4718 KiB  
Article
Effects of Indole-3-Lactic Acid, a Metabolite of Tryptophan, on IL-4 and IL-13-Induced Human Skin-Equivalent Atopic Dermatitis Models
by Kyunghee Kim, Hyeju Kim and Gun Yong Sung
Int. J. Mol. Sci. 2022, 23(21), 13520; https://doi.org/10.3390/ijms232113520 - 4 Nov 2022
Cited by 11 | Viewed by 4111
Abstract
Indole-3-lactic acid (I3LA) is a well-known metabolite involved in tryptophan metabolism. Indole derivatives are involved in the differentiation of immune cells and the synthesis of cytokines via the aryl hydrocarbon receptors for modulating immunity, and the indole derivatives may be involved in allergic [...] Read more.
Indole-3-lactic acid (I3LA) is a well-known metabolite involved in tryptophan metabolism. Indole derivatives are involved in the differentiation of immune cells and the synthesis of cytokines via the aryl hydrocarbon receptors for modulating immunity, and the indole derivatives may be involved in allergic responses. I3LA was selected as a candidate substance for the treatment of atopic dermatitis (AD), and its inhibitory effect on AD progression was investigated. Full-thickness human skin equivalents (HSEs) consisting of human-derived cells were generated on microfluidic chips and stimulated with major AD-inducing factors. The induced AD-HSEs were treated with I3LA for 7 days, and this affected the AD-associated genetic biomarkers and increased the expression of the major constituent proteins of the skin barrier. After the treatment for 14 days, the surface became rough and sloughed off, and there was no significant difference between the increased AD-related mRNA expression and the skin barrier protein expression. Therefore, the short-term use of I3LA for approximately one week is considered to be effective in suppressing AD. Full article
(This article belongs to the Special Issue Interconnecting Cytokine-Associated Molecular Pathways and Pathogenesis of Inflammatory Skin Diseases 2.0)
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Review

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16 pages, 1465 KiB  
Review
Antioxidants in Photoaging: From Molecular Insights to Clinical Applications
by María José Calvo, Carolina Navarro, Pablo Durán, Nataly J. Galan-Freyle, Luis Alberto Parra Hernández, Leonardo C Pacheco-Londoño, Desiree Castelanich, Valmore Bermúdez and Maricarmen Chacin
Int. J. Mol. Sci. 2024, 25(4), 2403; https://doi.org/10.3390/ijms25042403 - 18 Feb 2024
Cited by 4 | Viewed by 2188
Abstract
Photoaging (PA) is considered a silent disease affecting millions of people globally and is defined as skin damage due to prolonged exposure to ultraviolet radiation (UVR) from the sun. Physiologically, the skin is in a state of renewal and synthesis of components of [...] Read more.
Photoaging (PA) is considered a silent disease affecting millions of people globally and is defined as skin damage due to prolonged exposure to ultraviolet radiation (UVR) from the sun. Physiologically, the skin is in a state of renewal and synthesis of components of the extracellular matrix (ECM). However, exposure to UVR affects the production of the ECM, and the functioning and response of skin cells to UVR begins to change, thus expressing clinical and phenotypic characteristics of PA. The primary mechanisms involved in PA are direct damage to the DNA of skin cells, increases in oxidative stress, the activation of cell signaling pathways responsible for the loss of skin integrity, and cytotoxicity. The medical and scientific community has been researching new therapeutic tools that counteract PA, considering that the damage caused by UVR exceeds the antioxidant defense mechanisms of the skin. Thus, in recent years, certain nutraceuticals and phytochemicals have been found to exhibit potential antioxidant and photoprotective effects. Therefore, the main objective of this review is to elucidate the molecular bases of PA and the latest pharmaceutical industry findings on antioxidant treatment against the progression of PA. Full article
(This article belongs to the Special Issue Interconnecting Cytokine-Associated Molecular Pathways and Pathogenesis of Inflammatory Skin Diseases 2.0)
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11 pages, 265 KiB  
Review
The Genetic Susceptibility to Psoriasis and the Relationship of Linked Genes to Our Treatment Options
by Heli A. Patel, Rishab R. Revankar, Sofia T. Pedroza, Shaveonte Graham and Steven R. Feldman
Int. J. Mol. Sci. 2023, 24(15), 12310; https://doi.org/10.3390/ijms241512310 - 1 Aug 2023
Cited by 2 | Viewed by 2150
Abstract
Understanding the factors creating genetic susceptibility in psoriasis may provide a basis for improving targeted treatment strategies. In this review, we discuss the genes linked to the pathogenesis of psoriasis and their relationship to the available treatment options. To identify the relevant genetic [...] Read more.
Understanding the factors creating genetic susceptibility in psoriasis may provide a basis for improving targeted treatment strategies. In this review, we discuss the genes linked to the pathogenesis of psoriasis and their relationship to the available treatment options. To identify the relevant genetic markers and treatments, we searched PubMed, Google Scholar, MEDLINE, and Web of Science with keywords, including genetic susceptibility to psoriasis, genetics and psoriasis, psoriasis treatments, and biologics treatments in psoriasis. The articles in English from database inception to 1/1/23 were included. Case reports and series were excluded. Gene variant forms commonly implicated in the pathogenesis of psoriasis include those encoding for interleukins, interferons, and other mediators involved in inflammatory pathways, such as JAK/STAT, and NF-κB. Several of the treatments for psoriasis (for example IL23 and TYK2 inhibitors) target the products of genes linked to psoriasis. Multiple genes are linked to the pathogenesis of psoriasis. This understanding may provide an avenue for the development of new psoriasis treatment strategies and for more effective, safer treatment outcomes. Full article
(This article belongs to the Special Issue Interconnecting Cytokine-Associated Molecular Pathways and Pathogenesis of Inflammatory Skin Diseases 2.0)
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