Roles of Neutrophils in Autoimmune Diseases and Cancers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 79
Special Issue Editor
Interests: neutrophils; neutrophil extracellular traps; pediatric diseases, pediatric cancers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Research in the area of autoimmunity and cancers has mainly focused on adaptive immune responses and their broad applications. However, greater attention should be paid to the innate immune response, and especially to neutrophils, which play an invaluable role in host immune defense. Notably, successful neutrophil defense is often associated with inflammatory tissue damage and other disorders such as autoimmune diseases and cancers. This has been linked to the capability of activated neutrophils to release decondensed chromatin decorated with granular proteins known as neutrophil extracellular traps (NETs). NETs act as a scaffold for the aggregation of viable, necrotic and apoptotic cells, as well as crystals and microbes. However, neutrophils have more roles alongside their capability to release NETs, and they are also known as phagocytocic cells, degranulating and producing reactive oxygen species (ROS) among other functions.
Although significant efforts have been made to study neutrophils and NETs in the context of autoimmune diseases and cancer, we still need to broaden our knowledge to develop new and better therapeutical solutions. Therefore, the focus of this Special Issue is to update current research on neutrophils and their various mechanisms of action in autoimmunity and cancer, improving our understanding and enabling the development of new therapeutic strategies. Both review and original articles covering basic, translational or clinical molecular-data-supported research are welcome.
Dr. Jasmin Knopf
Guest Editor
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Keywords
- neutrophils
- neutrophil extracellular traps (NETs)
- autoimmunity
- autoimmune disease(s)
- cancer
- oncology
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