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Advances in Antimicrobial Nanomaterials 2.0
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Advances in Antimicrobial Nanomaterials 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 4075

Special Issue Editor

Prof. Dr. Irena Maliszewska

E-Mail Website
Guest Editor
Department of Organic and Medicinal Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland
Interests: synthesis of metallic nanoparticles; nanofibers; antimicrobial activity; photodynamic therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The problem of the presence of multidrug-resistant bacteria in the human environment has worsened the difficult clinical situation due to the reduced antimicrobial activity of known antibiotics. An example of such microbes is the group of pathogenic bacteria called ESKAPE. The acronym ESKAPE consists of the first letters of the generic names of the following bacteria: Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacteriaceae. This acronym covers bacterial pathogens that cannot be eliminated using classical antibiotics.

In addition, there is a growing concern regarding infections associated with the biofilm formation, which may be resistant to the currently available arsenal of antimicrobial agents. Therefore, there is an urgent need to develop alternative protocols for combating antimicrobial resistance to chemotherapeutic drugs.

Over the last two decades, there has been a significant increase in the use of nanodrugs as innovative tools to combat the antimicrobial resistance of pathogens. In this respect, nanomaterials have shown promise due to their unique physical and chemical properties. Their large surface in relation to the volume allows for close interaction with microbial membranes as well as their surface functionalization. Scientists are primarily interested in metal nanoparticles as innovative tools to combat pathogen resistance to conventional antimicrobial agents. The antimicrobial activity of several metals, metal oxides, metal halides, and bimetallic nanoparticles has been well documented. Moreover, the functionalization of nanoparticles using chemotherapeutic drugs is not only a promising nanoplatform for combating bacterial resistance but may also reduce the dose of the drug and, thus, its toxicity.

On the other hand, antimicrobial nanoparticles can be entrapped in polymer membranes to form hybrid nanoparticles or nanocomposites. It is also possible to improve the therapeutic efficacy of nanoparticles and reduce their toxicity by modifying the surface using ligands or antibodies.

We are interested in manuscripts that report new antimicrobial protocols related to various nano-sized materials but also provide reviews of the subject.

Prof. Dr. Irena Maliszewska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metallic nanoparticles
  • bimetallic nanoparticles
  • antimicrobial activity
  • polymeric nanomaterials
  • nanoplatforms
  • nanoparticle functionalization
  • delivery of antimicrobial agents

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Published Papers (2 papers)

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Research

12 pages, 1545 KiB  
Article
Study of the Antibacterial Activity of Superhydrophilic and Superhydrophobic Copper Substrates against Multi-Drug-Resistant Hospital-Acquired Pseudomonas aeruginosa Isolates
by Natalia E. Bondareva, Anna B. Sheremet, Elena Y. Morgunova, Irina R. Khisaeva, Alisa S. Parfenova, Marina Y. Chernukha, Fadi S. Omran, Alexandre M. Emelyanenko and Ludmila B. Boinovich
Int. J. Mol. Sci. 2024, 25(2), 779; https://doi.org/10.3390/ijms25020779 - 8 Jan 2024
Cited by 6 | Viewed by 1471
Abstract
The global spread of multidrug-resistant (MDR) hospital-acquired pathogens is a serious problem for healthcare units. The challenge of the spreading of nosocomial infections, also known as hospital-acquired pathogens, including Pseudomonas aeruginosa, must be addressed not only by developing effective drugs, but also by [...] Read more.
The global spread of multidrug-resistant (MDR) hospital-acquired pathogens is a serious problem for healthcare units. The challenge of the spreading of nosocomial infections, also known as hospital-acquired pathogens, including Pseudomonas aeruginosa, must be addressed not only by developing effective drugs, but also by improving preventive measures in hospitals, such as passive bactericidal coatings deposited onto the touch surfaces. In this paper, we studied the antibacterial activity of superhydrophilic and superhydrophobic copper surfaces against the P. aeruginosa strain PA103 and its four different polyresistant clinical isolates with MDR. To fabricate superhydrophilic and superhydrophobic coatings, we subjected the copper surfaces to laser processing with further chemosorption of fluorooxysilane to get a superhydrophobic substrate. The antibacterial activity of superhydrophilic and superhydrophobic copper surfaces was shown, with respect to both the collection strain PA103 and polyresistant clinical isolates of P. aeruginosa, and the evolution of the decontamination of a bacterial suspension is presented and discussed. The presented results indicate the promising potential of the exploitation of superhydrophilic coatings in the manufacture of contact surfaces for healthcare units, where the risk of infection spread and contamination by hospital-acquired pathogens is extremely high. Full article
(This article belongs to the Special Issue Advances in Antimicrobial Nanomaterials 2.0)
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16 pages, 2172 KiB  
Article
Evaluation of Antibacterial Mechanism of Action, Tyrosinase Inhibition, and Photocatalytic Degradation Potential of Sericin-Based Gold Nanoparticles
by Gitishree Das and Jayanta Kumar Patra
Int. J. Mol. Sci. 2023, 24(11), 9477; https://doi.org/10.3390/ijms24119477 - 30 May 2023
Cited by 7 | Viewed by 2206
Abstract
In recent times, numerous natural materials have been used for the fabrication of gold nanoparticles (AuNPs). Natural resources used for the synthesis of AuNPs are more environment friendly than chemical resources. Sericin is a silk protein that is discarded during the degumming process [...] Read more.
In recent times, numerous natural materials have been used for the fabrication of gold nanoparticles (AuNPs). Natural resources used for the synthesis of AuNPs are more environment friendly than chemical resources. Sericin is a silk protein that is discarded during the degumming process for obtaining silk. The current research used sericin silk protein waste materials as the reducing agent for the manufacture of gold nanoparticles (SGNPs) by a one-pot green synthesis method. Further, the antibacterial effect and antibacterial mechanism of action, tyrosinase inhibition, and photocatalytic degradation potential of these SGNPs were evaluated. The SGNPs displayed positive antibacterial activity (8.45–9.58 mm zone of inhibition at 50 μg/disc) against all six tested foodborne pathogenic bacteria, namely, Enterococcus feacium DB01, Staphylococcus aureus ATCC 13565, Listeria monocytogenes ATCC 33090, Escherichia coli O157:H7 ATCC 23514, Aeromonas hydrophila ATCC 7966, and Pseudomonas aeruginosa ATCC 27583. The SGNPs also exhibited promising tyrosinase inhibition potential, with 32.83% inhibition at 100 μg/mL concentration as compared to 52.4% by Kojic acid, taken as a reference standard compound. The SGNPs also displayed significant photocatalytic degradation effects, with 44.87% methylene blue dye degradation after 5 h of incubation. Moreover, the antibacterial mode of action of the SGNPs was also investigated against E. coli and E. feacium, and the results show that due to the small size of the nanomaterials, they could have adhered to the surface of the bacterial pathogens, and could have released more ions and dispersed in the bacterial cell wall surrounding environment, thereby disrupting the cell membrane and ROS production, and subsequently penetrating the bacterial cells, resulting in lysis or damage to the cell by the process of structural damage to the membrane, oxidative stress, and damage to the DNA and bacterial proteins. The overall outcome of the current investigation concludes the positive effects of the obtained SGNPs and their prospective applications as a natural antibacterial agent in cosmetics, environmental, and foodstuff industries, and for the management of environmental contagion. Full article
(This article belongs to the Special Issue Advances in Antimicrobial Nanomaterials 2.0)
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