Immune Cell Signaling and Immune Metabolism in Inflammatory Processes

Dear Colleagues,

Over the past few years it has become evident that immune cell signaling regulates the energy metabolism of adaptive as well as innate immune cells. In T cells, antigen recognition by the T-cell receptor (TCR) results in the activation of different transcription factors regulating the expression of genes encoding for key metabolic enzymes. Similarly, signaling via non-adaptive sensing receptors such as Toll-like receptors (TLRs) stimulate metabolic reprogramming in innate immune cells. It has also become evident that the energy metabolism affects several immune cell functions and hence, it plays an essential role in the regulation of immune responses. Thus, the better understanding of how signaling processes regulate metabolic pathways in adaptive and innate immune cells will provide new avenues for the development of new therapeutic approaches to modulate immune responses and to ameliorate inflammatory diseases.

The Special Issue “Immune Cell Signaling and Immune Metabolism in Inflammatory Processes” welcomes original research and review articles with a particular focus on the interconnection of immune cell signaling and immunometabolism during inflammation.

Prof. Dr. Luca Simeoni
Prof. Dr. Sascha Kahlfuss
Guest Editors

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