The Role of Oxidative Stress in Neurodegenerative Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (15 February 2024) | Viewed by 757
Special Issue Editor
Interests: singlet oxygen; oxidative stress; Alzheimer's diseases; α-synuclein Parkinson's diseases; proteinaceous diseases
Special Issue Information
Dear Colleagues,
Oxidative stress is known to play an important role in the pathogenesis of many diseases. It occurs from the imbalance between the production of reactive oxygen species (ROS) and their elimination by protective mechanisms. The Neurodegenerative Diseases include diseases such as Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, etc.
Singlet oxygen is an excited state of oxygen O2 which readily oxidizes cellular components such as lipids, proteins, nucleic acids and others. The energy needed for the excitation of oxygen from the ground to the first excited state 1Δg, indicating singlet oxygen, is equal to 92 kJ mol−1. For proteinaceous diseases, the calculated ΔG≠ values vary between 92.8 and 127 kJ mol−1 at 310 K. For reactions in general, a value of 10–30 kJ mol−1 is the requisite activation energy for the diffusion of reactants depending on the reaction and the medium. The similarity of the ΔG≠ values is an indication that a common mechanism may be taking place in the above disorders. We may attribute this common mechanism to the (same) role of the oxidative stress and specifically to that of singlet oxygen (1ΔG).
This Special Issue aims to present the latest research regarding the role of oxidative stress in neurodegenerative diseases. Both original research articles and reviews are welcome.
Dr. Athinoula Petrou
Guest Editor
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Keywords
- singlet oxygen
- oxidative stress
- first excited state of oxygen
- neurodegenerative diseases
- β-amyloid protein Alzheimer's diseases
- tau protein Alzheimer's diseases
- Pick's diseases
- α-synuclein Parkinson's diseases
