Cellular Metabolism and Retinal Diseases: Unraveling Molecular Pathways and Therapeutic Targets
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 59
Special Issue Editors
Interests: diabetes; retinopathy; VEGF-A; IGF-1; advanced glycation end-products
Special Issues, Collections and Topics in MDPI journals
Interests: the role of caveoles in the insulin and IGF1 signal; new technologies in the treatment of diabetes mellitus; role of bariatric surgery in the regulation of metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The retina is one of the most metabolically active tissues in the body, its different cell types organized in layers with close metabolic symbiotic exchanges between the cellular components. In particular, the retinal pigment epithelium (RPE) supplies nutrients from the choroidal vasculature to all retinal cellular components. However, the high metabolic demands depend on the nutrient supply. Therefore, the retina may be considered a metabolic ecosystem in which RPE cell dysfunction may compromise the function and viability of other retinal cells. RPE can use a lot of fuels, such as glucose, amino acids, lactic acid, and lipids, to produce energy. The disruption of the local energy supply may affect the redox balance, contributing to a disrupted retinal homeostasis. Moreover, metabolites affect epigenetic modifications, linking the cellular metabolism to transcriptional activity.
It is well known that the pathogenesis of retinal diseases, including age-related macular degeneration and diabetic retinopathy, is associated with retinal metabolism dysregulation. This Special Issue aims to provide new insights into the metabolic mechanisms at the basis of retinal diseases, supporting new therapeutic targets.
Dr. Alessandra Puddu
Dr. Davide Maggi
Guest Editors
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Keywords
- retina
- metabolic dysfunction in retinal diseases
- metabolism and retinal cell function
- metabolism and oxidative stress
- therapeutic targets
- intracellular signaling
- epigenetic modification
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