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Role of Diet and Nutrition in Metabolic Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 1295

Special Issue Editor


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Guest Editor
Biomedical Research Unit, Mexican Institute of Social Security IMSS, Durango ZC 34067, Mexico
Interests: diabetes; insulin resistance; glucose metabolism; lipid metabolism; abdominal obesity

Special Issue Information

Dear Colleagues,

The health burden of metabolic diseases such as obesity, metabolic syndrome, type 2 diabetes, hypertension, and dyslipidemia is increasing worldwide and understanding the molecular mechanisms that food and nutrition exert on the development of these diseases will, undoubtedly, make it possible to plan of preventive and management interventions for the improving of patients’ health status. In this regard, the identification of molecular targets and biomarkers for early diagnosis and prevention, as well as new approaches to improving nutritional status, emerge as a public health priority. The aim of this Special Issue is to publish the results of current and up-to-date research that provides a better understanding how diet and nutritional status are related to metabolic diseases. Original and review manuscripts regarding biomarkers for the early identification of risk and prognosis, about pathophysiological pathways binding diet and disease, new molecular targets, associations of specific nutrients with metabolic diseases, and new therapeutic approaches are all welcome.

This Special Issue is supervised by Dr. Fernando Guerrero-Romero and assisted by our Topical Advisory Panel Member Claudia I. Gamboa-Gomez (Unidad de Investigación Biomédica, Instituto Mexicano del Seguro Social).

Dr. Fernando Guerrero-Romero
Guest Editor

Manuscript Submission Information

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Keywords

  • nutrients
  • biomarkers
  • molecular targets
  • pahodiagnosis
  • treatment

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Published Papers (1 paper)

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Research

14 pages, 1055 KiB  
Article
The Link between Salivary Amylase Activity, Overweight, and Glucose Homeostasis
by Gita Erta, Gita Gersone, Antra Jurka and Pēteris Tretjakovs
Int. J. Mol. Sci. 2024, 25(18), 9956; https://doi.org/10.3390/ijms25189956 - 15 Sep 2024
Viewed by 1140
Abstract
Butyrate, a short-chain fatty acid (SCFA) produced by the fermentation of dietary fibers in the colon, plays a pivotal role in regulating metabolic health, particularly by enhancing insulin sensitivity. Given the rising incidence of metabolic disorders, understanding the factors that influence butyrate production [...] Read more.
Butyrate, a short-chain fatty acid (SCFA) produced by the fermentation of dietary fibers in the colon, plays a pivotal role in regulating metabolic health, particularly by enhancing insulin sensitivity. Given the rising incidence of metabolic disorders, understanding the factors that influence butyrate production is of significant interest. This study explores the link between salivary amylase activity and butyrate levels in overweight women of reproductive age. Participants were categorized into low (LSA) and high (HSA) salivary amylase activity groups and further divided into two subgroups: one followed a low-starch diet (LS), and the other underwent caloric restriction (CR). We assessed salivary amylase activity and measured serum butyrate concentrations to examine their associations. Our findings showed a significant, though weak, positive correlation (ρ = 0.0486, p < 0.05), suggesting a link between salivary amylase activity and butyrate levels. The statistical significance, despite the weak correlation, implies that this relationship is not random. Moreover, higher baseline butyrate levels were observed in women with elevated salivary amylase activity. Also, women with low salivary amylase activity on a low-starch diet experienced a more pronounced increase in butyrate levels compared to those on caloric restriction. These results suggest that salivary amylase activity and dietary intake interact to influence butyrate production, with potential implications for improving insulin sensitivity and metabolic health. The study underscores the potential of butyrate in enhancing insulin sensitivity and promoting overall metabolic well-being. Further research is necessary to clarify the mechanisms involved and to understand the long-term effects of butyrate on metabolic health across different populations. Full article
(This article belongs to the Special Issue Role of Diet and Nutrition in Metabolic Diseases)
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