Advances in Peptide Research: From Chemistry to Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1568
Special Issue Editor
Interests: antibody-drug conjugates; bioconjugate chemistry; peptide therapeutics; cancer targeted therapy; peptide chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The evolution of peptide synthesis techniques has profoundly transformed the foundation of peptide research. Initial methods were laborious and produced limited peptide quantities. However, the modernization of solid-phase peptide synthesis (SPPS) marked a revolutionary turning point by enabling an automated and efficient peptide production. This advancement not only elevated yields but also facilitated the creation of longer and more intricate peptide structures. Furthermore, the introduction of novel protective groups, coupling agents, and orthogonal chemistry has expanded the range of amino acids that can be incorporated into peptides. This expansion has empowered the design of peptides with diverse structures, properties, and functions, spanning from simple linear to complex cyclic and branched arrangements. These achievements have played a pivotal role in catalyzing the development of over 80 peptide-based drugs that have made their way to the market, effectively addressing an extensive range of diseases. These encompass, among others, cancer, metabolic disorders, cardiovascular disorders, respiratory disorders, gastrointestinal disorders, infectious diseases, pain management, dermatological disorders, neurological disorders, and renal disorders. As research continues to advance, peptides are poised to play an increasingly substantial role in shaping the trajectory of medicine and biotechnology. In this context, the objective of this Special Issue of IJMS is to capture the captivating realm surrounding the progress in peptide research, spanning the spectrum from chemistry to therapeutics.
Dr. Iman Kavianinia
Guest Editor
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