The Transcriptome Complexity in Cancer and Leukemia: Alternative Splicing and Beyond

Dear Colleagues,

The complexity and diversity of the human transcriptome have been in the center of transcriptomics for more than two decades. Alternative splicing is a key biological process in human cells, as primary transcripts from more than 95% of human multi-exon genes are subjected to alternative splicing, during their post-transcriptional maturation. Due to its key role, its deregulation has been characterized as one of the hallmarks of cancer and hematological malignancies, while its targeting is considered as a promising therapeutic strategy.

This Special Issue focuses on the information of the readers regarding the contribution of alternative splicing of primary RNA molecules to transcriptome diversity and complexity, particularly in human cancer and leukemia. The authors are encouraged to submit their original research studies concerning this topic. Review articles will also be taken into consideration. The Guest Editor is willing to evaluate also manuscripts describing other aspects of transcriptomics, proposed by the authors.

Dr. Christos K. Kontos
Guest Editor

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