The Brain as a Manager of the Body—Molecular Aspects of Development and Functioning in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 27708
Special Issue Editor
2. Institute of Developmental Biology of the Russian Academy of Sciences, Moscow, Russia
Interests: developmental neurobiology; neuroendocrinology; neurodegenerative diseases; Parkinson’s disease; preclinical diagnosis; preventive neuroprotective therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The brain can be considered with certainty the conductor or manager of the development and functioning of the body. Indeed, it provides nervous and neuroendocrine regulations of the most important functions of the body, such as adaptation to the environment and maintenance of homeostasis, reproduction, various types of behavior, including motor behavior, and cognitive and other functions. Both types of regulation are provided by neuronal ensembles that exchange information using a wide range of intercellular signals—classical, neurotransmitters, neuropeptides, amino acids. With both types of regulation, the chemical signals are involved in synaptic or volume neurotransmission in the brain, while at the last stage of neuroendocrine regulation, the same physiologically active substances are released into the bloodstream, exerting a direct or indirect (through the pituitary gland) hormonal effect on peripheral target organs. The action of intercellular signaling in the brain during ontogenesis is fundamentally different from that in adulthood. Thus, in the perinatal period, they exert an irreversible effect on differentiating target neurons and the brain as a whole. In addition, in the absence of the blood–brain barrier during this period of ontogenesis, brain-derived chemical signals are delivered to the general circulation, affecting peripheral target organs and the brain itself (autoregulation). Impairment of the brain operation in adulthood leads to the development of numerous neurological, mental, and neuroendocrine diseases, which are more or less treatable. Disruption of the functioning of the developing brain during the critical period of morphogenesis (the perinatal period) leads to the development of congenital diseases that are practically not treatable during subsequent life.
Thus, this Special Issue of IJMS on “The Brain as a Manager of the Body—Molecular Aspects of Development and Functioning in Health and Disease” is open to a wide range of studies on the molecular mechanisms of brain functioning in adulthood and in ontogenesis in health and in brain diseases. Studies on cells, animals, and humans are welcome.
Prof. Dr. Michael Ugrumov
Guest Editor
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Keywords
- brain
- animals
- humans
- neural regulation
- neuroendocrine regulation
- synaptic neurotransmission
- volume neurotransmission
- ontogenesis
- body fluids
- blood
- blood–brain barrier
- brain diseases
- congenital diseases
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