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Inflammatory Biomarkers in Ischemic Stroke

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 1001

Special Issue Editors


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Guest Editor
Department of Medical Biology and Biochemistry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland
Interests: oxidative stress; inflammation; stroke

E-Mail Website
Guest Editor
Department of Medical Biology and Biochemistry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland
Interests: stroke

Special Issue Information

Dear Colleagues,

This Special Issue is supervised by Dr. Hanna Pawluk, Dr. Renata Kołodziejska, and assisted by our Topical Advisory Panel Member Rakesh B. Patel (University of IOWA).

Stroke is one of the most serious diseases, often leading to significant disability or death. Brain tissue damage during ischemic stroke and subsequent pathological processes are mediated by multiple molecular pathways that are modulated by inflammatory markers. Studying the mechanisms contributing to the development of hypoxia tolerance in cells and tissues may not only be of great theoretical importance but is also necessary to solve many problems in practical medicine. The analysis of biochemical parameters will allow us to understand how inflammation contributes to the progression of the stroke focus in the course of cerebral circulation disorders. This may be a valuable clue for modulating immune response mechanisms in order to limit damage to neural tissue after ischemia.

This Special Issue welcomes original papers and reviews dealing with the implications of inflammatory biomarkers on the diagnosis and prognosis of ischemic stroke.

Dr. Hanna Pawluk
Dr. Renata Kołodziejska
Guest Editors

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Keywords

  • stroke
  • brain tissue damage
  • ischemic stroke
  • inflammatory markers
  • immune response

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Published Papers (1 paper)

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Research

14 pages, 2546 KiB  
Article
Differences in Acute Expression of Matrix Metalloproteinases-9, 3, and 2 Related to the Duration of Brain Ischemia and Tissue Plasminogen Activator Treatment in Experimental Stroke
by Dong Wang, Sofiyan Saleem, Ryan D. Sullivan, Tieqiang Zhao and Guy L. Reed
Int. J. Mol. Sci. 2024, 25(17), 9442; https://doi.org/10.3390/ijms25179442 - 30 Aug 2024
Viewed by 749
Abstract
Matrix metalloproteinases (MMPs) such as MMP-9, 3, and 2 degrade the cellular matrix and are believed to play a crucial role in ischemic stroke. We examined how the duration of ischemia (up to 4 h) and treatment with recombinant tissue plasminogen activator altered [...] Read more.
Matrix metalloproteinases (MMPs) such as MMP-9, 3, and 2 degrade the cellular matrix and are believed to play a crucial role in ischemic stroke. We examined how the duration of ischemia (up to 4 h) and treatment with recombinant tissue plasminogen activator altered the comparative expression of these MMPs in experimental ischemic stroke with reperfusion. Both prolonged ischemia and r-tPA treatment markedly increased MMP-9 expression in the ischemic hemisphere (all p < 0.0001). The duration of ischemia and r-tPA treatment also significantly increased MMP-2 expression (p < 0.01–0.001) in the ischemic hemisphere (p < 0.01) but to a lesser degree than MMP-9. In contrast, MMP-3 expression significantly decreased in the ischemic hemisphere (p < 0.001) with increasing duration of ischemia and r-tPA treatment (p < 0.05–0001). MMP-9 expression was prominent in the vascular compartment and leukocytes. MMP-2 expression was evident in the vascular compartment and MMP-3 in NeuN+ neurons. Prolonging the duration of ischemia (up to 4 h) before reperfusion increased brain hemorrhage, infarction, swelling, and neurologic disability in both saline-treated (control) and r-tPA-treated mice. MMP-9 and MMP-2 expression were significantly positively correlated with, and MMP-3 was significantly negatively correlated with, infarct volume, swelling, and brain hemorrhage. We conclude that in experimental ischemic stroke with reperfusion, the duration of ischemia and r-tPA treatment significantly altered MMP-9, 3, and 2 expression, ischemic brain injury, and neurological disability. Each MMP showed unique patterns of expression that are strongly correlated with the severity of brain infarction, swelling, and hemorrhage. In summary, in experimental ischemic stroke in male mice with reperfusion, the duration of ischemia, and r-tPA treatment significantly altered the immunofluorescent expression of MMP-9, 3, and 2, ischemic brain injury, and neurological disability. In this model, each MMP showed unique patterns of expression that were strongly correlated with the severity of brain infarction, swelling, and hemorrhage. Full article
(This article belongs to the Special Issue Inflammatory Biomarkers in Ischemic Stroke)
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