Chimeric Antigen Receptors against Cancers and Autoimmune Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 152
Special Issue Editor
Interests: CAR-T cells; melanoma; adoptive cell therapy; cancer vaccination; cancer immunotherapy; solid tumors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The development of chimeric antigen receptors (CARs) has marked a new era in cancer immunotherapy. Tremendous clinical advances have been achieved via the use of CAR-T cells against a variety of cancers both in preclinical studies and in clinical trials, most notably against leukemia, lymphoma, and multiple myeloma; these studies have resulted in the FDA and EMA approval of these CAR-T-cell therapies. Nevertheless, approximately 50% of patients treated with these approved CAR products experience relapse or refractory disease that necessitates salvage strategies. Furthermore, in patients with solid tumors, CAR-T-cell infusions have not yet been able to induce complete and durable remission. Very recently, the clinical efficacy of CAR-T cells was also proven in patients with autoimmune diseases.
Due to the rapid evolution of this field, the aim of this Special Issue is to focus on advancements and novel strategies regarding CARs for the therapy of cancer and autoimmune diseases.
Prof. Dr. Niels Schaft
Guest Editor
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Keywords
- chimeric antigen receptor (CAR)
- cancer
- autoimmune disease
- solid tumor
- effector cell
- CAR format
- CAR transfer
- tumor microenvironment
- targeted antigen
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