Advances in Regenerative Medicine, Organ Bioengineering and Transplantation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 64
Special Issue Editor
Interests: regenerative medicine; organ bioengineering; transplantation; drug discovery; immunosuppression
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
An increase in life expectancy is accompanied by chronic diseases and organ failure, while an increase in cancer-related or inflammatory diseases contributes to premature organ failure. In organ transplantation, allograft rejection represents a major problem that could be overcome with recent advances in immunosuppressive medications. Current drug targets and signaling pathways used for immunosuppression include calcineurin, mTOR signaling, purine and amino acid synthesis and metabolism, the complement system, cytokine networks, etc. However, the standard pharmacotherapy applied after transplantation can generate toxicity and thus is not optimal, while usage of induced pluripotent stem cells can be tumorigenic. Nevertheless, multipotent adult progenitor cells for organoid generation and interspecies blastocyst complementation open new avenues in regenerative medicine.
All new immunosuppressive drug therapies preventing allograft rejection are welcome in this issue. Original articles or reviews proposing new therapeutic strategies for post-transplantation treatment are particularly suitable. New technologies for transplantation and bioengineering that offer safe and ethical therapies for organ regeneration will bring attention. Articles that improve the understanding of extracellular matrix interactions associated with the efficient application of decellularization in tissue engineering are welcome.
Dr. Dorota Latek
Guest Editor
Manuscript Submission Information
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Keywords
- regenerative medicine
- organ bioengineering
- transplantation
- allografting
- stem cells
- drug discovery
- immunosuppression
- xenotransplantation
- organogenesis
- biomaterials
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