Novel Strategies in the Development of New Anti-inflammatory Drug Substances and Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 11879
Special Issue Editor
Interests: sex differences in inflammatory diseases and implications for sex-related therapy; pathobiochemistry of inflammation; molecular and biochemical pharmacology of natural and synthetic anti-inflammatory molecules
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Many inflammatory diseases are high-burden conditions for which the currently available treatment is inadequate. To date, non-steroidal anti-inflammatory drugs inhibiting prostaglandin production, represent the most important anti-inflammatory therapeutic class. Although, their use is often plagued by efficacy and safety issues, leading to very expensive and serious adverse reactions. Inflammation is a very complex pathophysiological process, involving a myriad of enzymes, mediators, and receptors, producing proinflammatory and anti-inflammatory molecules. In particular, pharmacological modulation of a single target tends to generate shunting phenomena that can compromise therapeutic efficacy. Thus, there is a clear need to develop anti-inflammatory drugs with novel mechanisms and/or multitarget action that are able to overcome the delicate balance between providing a therapeutic effect while minimizing side effects. Topics will include (but are not limited to):
- Individuation of new targets for anti-inflammatory therapy
- Natural products as novel therapeutic strategies
- New synthetic compounds with anti-inflammatory proprieties.
Dr. Antonietta Rossi
Guest Editor
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Keywords
- acute and chronic inflammatory diseases
- multitarget therapy
- lipid mediators
- in vitro and in vivo studies
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