Next-Gen Tissue Engineering in Disease Modelling, Drug Discovery and Immunotherapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 52
Special Issue Editor
Interests: leukaemia; cancer cell dormancy; drug resistance; measurable residual disease; liquid biopsy & cancer biomarkers; stress response; microenvironment-dependent drug resistance; organ-on-a-chip; bioengineered 3D microenvironments
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Special Issue Information
Dear Colleagues,
Traditional 2D cell culture and animal models, while valuable, often fall short in replicating the human tissue microenvironment. It is also true that as science evolves, the ethical and regulatory scrutiny of animal use in research increases. Many countries are now actively enforcing the extended view 3R’s of animal experimentation—replacement, reduction, refinement, relevance, reproducibility, and responsibility—driving a shift toward more humane and scientifically advanced methodologies.
In parallel, tissue engineering is rapidly transforming the biomedical landscape, offering unprecedented opportunities to model diseases, accelerate drug discovery, and evaluate the pre-clinical efficacy of immunotherapies and other cell-based therapies. By combining biomaterials, living cells, and engineering principles, tissue engineering allows for the creation of complex and functional systems that closely mimic human tissues and organs. Importantly, these advancements are now revolutionizing our understanding of disease mechanisms, improving therapeutic development, and offering new approaches for the clinical management of many diseases, ranging from oncology to regenerative medicine.
In this Special Issue, “Next-Gen Tissue Engineering in Disease Modelling, Drug Discovery and Immunotherapeutics”, we encourage the submission of original research articles, comprehensive reviews, protocols, and perspective papers that push the boundaries of tissue engineering and its application to disease modelling and therapeutic development. Through this Special Issue, we aim to highlight and open a critical discussion on how next-gen tissue engineering is reshaping biomedical research, offering novel insights that could have transformative effects on both basic science and clinical practise.
Therefore, topics of interest for this Special Issue include, but are not limited to, the following:
- Advances in 3D tissue culture and organoid models for disease studies.
- Integration of tissue engineering with drug discovery platforms.
- Microphysiological systems and organ-on-a-chip models for high-throughput drug screening.
- Tissue-engineered models for personalized medicine and therapeutic testing.
- Applications of bioprinting and biomaterials in regenerative medicine.
- Translational approaches for tissue-engineered constructs in clinical therapies.
I look forward to your contributions, and we are excited to share in the advancements that will continue to drive innovation in tomorrow’s medicine.
Dr. Hugo Ronaldo Freitas Caires
Guest Editor
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Keywords
- tissue engineering
- 3D cell culture
- biomaterials
- disease modelling
- immunotherapy
- cell-based therapies
- organ-on-a-chip
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