Cell Cycle-Related Proteins: Biochemical Regulative/Deregulative Mechanisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 1411
Special Issue Editor
Interests: CIP/KIP proteins; p57Kip2; p27Kip1; p53; cell cycle regulation and cell differentiation; DNA damage; post-translational modifications; phosphorylation; kinase inhibitors; natural compounds; mesenchymal stem cells; cancer; Bechwidth-Wiedemann syndrome; IMAGe; Russell-Silver syndrome; hypoxia-related diseases; iron metabolism
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Special Issue Information
Dear Colleagues,
Cell division is a finely tuned process in which post-translational modifications (PTMs) play a crucial role in modulating the stability, subcellular localization, and functions of Cyclins, Cyclin-Dependent Kinases (CDKs), and their regulators. To date, hundreds of PTMs have been reported to modulate the activity of cell cycle-related proteins. These modifications are essential for genome stability and the proper timing of cell cycle progression, especially during mitosis when transcriptional activity is limited, thus preventing abnormal cell division. However, full knowledge of their regulatory mechanisms is still lacking. To be noted, cell cycle-related proteins are involved in numerous additional biological processes, like transcription regulation, cell differentiation, DNA damage response, cytoskeleton remodeling, the regulation of metabolism, cell death, stem cell fate, senescence, and development, beyond the regulation of cell division. Indeed, their alterations lead to pathologies that range from growth-related diseases to degenerative diseases and, obviously, cancer. In addition, regarding cancer therapy, the discovery of peculiar PTMs of cell cycle-related proteins has been associated with the response to treatment with kinase inhibitors approved by the FDA. Thus, clarifying their biochemical regulation and deregulation is important to elucidate their impact on their physiological and pathological functions, and at the same time, in the era of precision medicine, it will contribute to the formulation of new therapeutic strategies.
This Special Issue will focus on the biochemical regulative and deregulative pathways of cell cycle-related proteins in health and various pathologies, in particular, cancer and growth-related diseases; on their role as sensitizing or resistance factors to therapy; on their therapeutic implications.
Dr. Emanuela Stampone
Guest Editor
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Keywords
- cell cycle
- cell division
- cyclins
- cyclin-dependent kinases (CDKs)
- biochemical regulative mechanisms
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