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New Molecular Research and Perspective: Microbiota and Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2925

Special Issue Editors


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Guest Editor
Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy
Interests: human tumor angiogenesis; innate immune cells in the tumor microenvironment; natural killer cells and macrophages in human cancers; evaluating novel immunotherapeutic interventions based on immunocitokynes TNF and IL-2, in combination setting against tumor development and metastasis in preclinical tumor murine models.
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E-Mail Website
Guest Editor
1. Immunology and General Pathology Laboratory, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy
2. Molecular Cardiology Laboratory, IRCCS-Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy
Interests: tumor microenvironment; angiogenesis; natural killer cells; tumor biology; extracellular vesicles; immunology; non-coding RNAs

Special Issue Information

Dear Colleagues,

The microbiota plays fundamental roles in the initiation, progression and therapy of cancer. This fact has been investigated, in particular, in the case of the intestinal microbiota but also for communities of microorganisms that colonize other districts of the body. In fact, the study of the interaction between microbiota and cancer has become, in only a few years, an extremely articulated field of investigation. In this Special Issue, we propose to investigate two aspects in particular: a) the study of the specific presence of particular species/strains of microbiota in the TME, even in tumors that originate in tissues commonly thought to be sterile, such as breast cancer; b) the microbiota ability to modulate neoangiogenesis in different pathological contexts, in particular, in the tumorigenesis. However, we invite authors to submit contributions in other investigative subareas as well. In particular, those of translational interests, thus the role of the microbiota in cancer chemotherapy and immunotherapy.

Dr. Lorenzo Mortara
Dr. Denisa Baci
Guest Editors

Manuscript Submission Information

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Keywords

  • cancer
  • microbiota/microbiome
  • tumor microenvironment
  • symbiosis
  • angiogenesis
  • inflammatory cells
  • metastasis
  • immunotherapies

Published Papers (1 paper)

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Review

23 pages, 884 KiB  
Review
The Urinary Microbiome in Health and Disease: Relevance for Bladder Cancer
by Natasa Kustrimovic, Giorgia Bilato, Lorenzo Mortara and Denisa Baci
Int. J. Mol. Sci. 2024, 25(3), 1732; https://doi.org/10.3390/ijms25031732 - 31 Jan 2024
Cited by 2 | Viewed by 2544
Abstract
Bladder cancer (BC) constitutes one of the most diagnosed types of cancer worldwide. Advancements in and new methodologies for DNA sequencing, leading to high-throughput microbiota testing, have pinpointed discrepancies in urinary microbial fingerprints between healthy individuals and patients with BC. Although several studies [...] Read more.
Bladder cancer (BC) constitutes one of the most diagnosed types of cancer worldwide. Advancements in and new methodologies for DNA sequencing, leading to high-throughput microbiota testing, have pinpointed discrepancies in urinary microbial fingerprints between healthy individuals and patients with BC. Although several studies suggest an involvement of microbiota dysbiosis in the pathogenesis, progression, and therapeutic response to bladder cancer, an established direct causal relationship remains to be elucidated due to the lack of standardized methodologies associated with such studies. This review compiles an overview of the microbiota of the human urinary tract in healthy and diseased individuals and discusses the evidence to date on microbiome involvement and potential mechanisms by which the microbiota may contribute to the development of BC. We also explore the potential profiling of urinary microbiota as a biomarker for risk stratification, as well as the prediction of the response to intravesical therapies and immunotherapy in BC patients. Further investigation into the urinary microbiome of BC patients is imperative to unravel the complexities of the role played by host–microbe interactions in shaping wellness or disease and yield valuable insights into and strategies for the prevention and personalized treatment of BC. Full article
(This article belongs to the Special Issue New Molecular Research and Perspective: Microbiota and Cancer)
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