Experimental Models and Applications in Muscle Regeneration
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 28
Special Issue Editor
Interests: cell death; survival mechanisms; intracellular signaling pathways; oxidative stress; adult human mesenchymal stem/stromal cells; tissue regeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Muscle tissue constitutes a significant portion of the human body, representing approximately 40–45% of total body weight in adult males and 30–35% in adult females. This includes all types of muscles: skeletal, smooth, and cardiac. Therefore, understanding the processes of muscle regeneration is essential for promoting a healthy, active life. Muscle regeneration is a complex and multifaceted process involving the coordinated action of stem and other muscle cells together with various extracellular matrix components. Interactions within 2D and 3D cellular environments, applying various biocomponents, biomaterials, internal and external stimuli, play a crucial role in regulating the intracellular signaling pathways, metabolism, and energetics essential for muscle regeneration. Despite the diverse mechanisms underlying regeneration across different muscle types—skeletal, cardiac, and smooth—the ongoing search for innovative approaches to enhance muscle regeneration remains highly relevant. To deepen our understanding of the regulatory mechanisms governing myogenic regeneration in vivo, the development and study of in vitro models are becoming increasingly important for therapeutic applications. This issue aims to explore novel 2D and 3D experimental models that focus on the targeted regulation of metabolic, energetic, and other myogenic processes, with the ultimate goal of expanding potential clinical applications to improve muscle regeneration.
Dr. Daiva Bironaite
Guest Editor
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Keywords
- stem cells
- internal and external stimuli
- scaffolds
- signaling systems
- muscle regeneration mechanisms
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