Regulation Mechanisms of Myogenic and Cardiomyogenic Differentiation
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 14192
Special Issue Editor
Interests: cell death; survival mechanisms; intracellular signaling pathways; oxidative stress; adult human mesenchymal stem/stromal cells; tissue regeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Myogenesis and cardiomyogenesis are complex processes that encompass adaptive tissue plasticity, regionalized responsiveness, the direct or indirect contribution of various types of cells, and inflammatory and metabolic processes. The mechanisms of skeletal and cardiac muscle regeneration, despite their diversity, occur within the environment of muscle tissue and include intracellular changes, intercellular cell-cell cross-talk, and systems of interaction between cellular networks and the extracellular matrix (ECM). Myogenic cell-cell or cell–ECM interactions usually respond to the local, regional, or systemic external and internal influences that affect stem cell differentiation and further muscle functioning. In order to better understand myogenic and cardiomyogenic differentiation processes and their regulation in vivo, various in vitro myogenic model systems are playing an increasingly important role. Muscle resident and tissue-specific cell progenitors can be an ideal candidate for myogenic differentiation and/or tissue regeneration purposes, but they are rare, difficult to identify and purify, and usually impossible to expand in culture. In addition, culture-adapted pluripotent stem cells (embryonic or iPS) are promising cells, in a scientific sense, that also exhibit ultimate therapeutic potential; their engraftment, differentiation, and cycling in the body should, however, be precisely controlled. The direct (intracellular, cell-cell, cell–ECM changes), indirect (growth factor secretory, immunomodulatory activity), or complex activity of multipotent (mesenchymal stem/stromal cells and other muscle-specific cell subpopulations) also participate in myogenic or cardiomyogenic differentiation.
Therefore, the aim of this issue is to investigate the mechanisms of myogenic and cardiomyogenic differentiation both in vitro and in vivo, searching for new external or internal inductors, cell types, ECM components, scaffolds, and other biomodulators that could improve the regeneration of skeletal and cardiac muscles, increasing the safety and efficiency associated with their clinical application.
Dr. Daiva Bironaité
Guest Editor
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Keywords
- stem cells
- myogenic differentiation
- cardiomyogenic differentiation
- regeneration
- model systems
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