ijms-logo

Journal Browser

Journal Browser

Molecular Immunology of Liver Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 591

Special Issue Editor


E-Mail Website
Guest Editor
Pharmaceutical Sciences Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Skaggs School, Aurora, CO 80045, USA
Interests: inflammatory liver diseases; complement; innate immunity; macrophages; type 3 cytokines; tissue fibrosis; steatotic liver disease

Special Issue Information

Dear Colleagues,

Chronic liver disease is a leading cause of mortality worldwide and non-resolving inflammation is critical driver of disease progression. While inflammation, occurring from the innate and adaptive immune system, precedes clinical manifestation of liver disease, there remain no therapeutic options for outside of liver transplant. In this special issue entitled "Molecular Immunology of Liver Diseases" in the International Journal of Molecular Sciences, we seek submissions filling gaps in knowledge that aim to uncover mechanisms related to immune dysregulation throughout the spectrum of liver disease, including steatosis, steatohepatitis, and liver fibrosis. This collection of original papers and reviews will seek to redefine the processes that govern inflammatory responses as well gain a better understanding how we can direct future studies to address increasing rates of chronic inflammatory liver disease world-wide. Submissions are encouraged to mechanistic in nature in areas of immunometabolism, organ-organ crosstalk (e.g., gut-liver, adipose-liver), oxidative eustress and/or distress, cellular signaling, transcriptional regulation and cytokine/chemokine networks.

Dr. Rebecca McCullough
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • steatotic liver disease
  • metabolic-associated liver disease
  • alcohol-associated liver disease
  • inflammation
  • innate immunity
  • adaptive immunity
  • liver fibrosis
  • biomarker discovery

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

20 pages, 1494 KiB  
Review
The Impact of Liver Failure on the Immune System
by Alicja Dąbrowska, Bartosz Wilczyński, Jakub Mastalerz, Julia Kucharczyk, Julita Kulbacka, Anna Szewczyk and Nina Rembiałkowska
Int. J. Mol. Sci. 2024, 25(17), 9522; https://doi.org/10.3390/ijms25179522 (registering DOI) - 1 Sep 2024
Viewed by 301
Abstract
Liver failure profoundly affects the immune system, leading to dysregulation of innate and adaptive immune response. This review explores the intricate relationship between liver function and immune homeostasis. The role of the liver as a central hub in immune response initiation is elucidated, [...] Read more.
Liver failure profoundly affects the immune system, leading to dysregulation of innate and adaptive immune response. This review explores the intricate relationship between liver function and immune homeostasis. The role of the liver as a central hub in immune response initiation is elucidated, emphasizing its involvement in hepatic inflammation induction and subsequent systemic inflammation. Cytokines, chemokines, growth factors, and lipid mediators orchestrate these immune processes, serving as both prognostic biomarkers and potential therapeutic targets in liver failure-associated immune dysregulation, which might result from acute-on-chronic liver failure (ACLF) and cirrhosis. Furthermore, the review delves into the mechanisms underlying immunosuppression in liver failure, encompassing alterations in innate immune cell functions such as neutrophils, macrophages, and natural killer cells (NK cells), as well as perturbations in adaptive immune responses mediated by B and T cells. Conclusion: Understanding the immunological consequences of liver failure is crucial for developing targeted therapeutic interventions and improving patient outcomes in liver disease management. Full article
(This article belongs to the Special Issue Molecular Immunology of Liver Diseases)
Show Figures

Figure 1

Back to TopTop