Anti-obesity Drug Discovery

Dear Colleagues,

Over the last 40 years, the obesity pandemic has been a challenge for economic prosperity and, from an individual perspective, a threat to the quality and length of life. As a chronic progressive disease, which is the gateway to a whole range of other chronic non-communicable diseases, it requires pharmacological treatment. Its premise is the recognition of physiological and eventually pathophysiological mechanisms that prevent and strengthen immuno-metabolic disturbances in obesity. Their subsequent influence at the level of molecular, cellular and central regulation is the promise of their correction in the prevention and treatment of obesity. The first anti-obesity drugs from the nutrient stimulated hormone-based therapy series show immense progress in obesity management. Therefore, this Special Issue is devoted to the current knowledge and perspectives in anti-obesity drug development.

Prof. Dr. Dana Mullerova
Guest Editor

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• gut-derived hormones and gut brain axis (nutrient stimulated hormone based therapy)
• other gut peptide-related approaches
• gut microbiome
• mitochondrial uncouplers (DNPME/CRMP)
• CNS secreted neuropeptides and antagonists
• adipose tissue hormones and adipokines