The Roles of Histamine and Its Receptor Ligands in Central Nervous System Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 1661
Special Issue Editor
Interests: neuropharmacology; neuroscience; drug discovery; brain histamine; brain carbonic anhydrases; oxytocin
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Despite the early diffidence in accepting the existence of a brain histaminergic system, its cardinal role in regulating several aspects of behavior is now well established. Indeed, this amine is crucial in maintaining arousal and plays a significant role in regulating circadian rhythms, energy, endocrine homeostasis, motor behavior, and cognition. Recent evidence suggests that histamine plays an important role in multiple central nervous system (CNS) disorders, including insomnia, narcolepsy, neurodegenerative diseases (Parkinson's and Alzheimer's diseases), schizophrenia, cerebral ischemia, and Tourette syndrome. New insights are emerging into the potential roles of histamine receptors as targets for the treatment of these diseases. Although some histaminergic ligands have failed in clinical trials, current preclinical studies suggest that this neurotransmitter may still have extensive applications in treating CNS disorders; nevertheless, advanced studies are warranted. This Special Issue welcomes findings from molecular research on the role of histamine and its receptor ligands in CNS disorders, including the development of novel histamine receptor ligands, with the goal of gaining an in-depth understanding of their potential mechanisms, cell-type role, and neural circuitry involved.
Dr. Gustavo Provensi
Guest Editor
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Keywords
- histamine
- histamine receptor
- neurodegenerative diseases
- sleep disorders
- neuropsychiatric disorders
- schizophrenia
- cognition
- heterogeneity
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