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Multi-Omics Analysis and Application of Plant Natural Products 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 1047

Special Issue Editor


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Guest Editor
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China
Interests: omics; natural product; anti-diabetes; neural protection; plant growth regulation; natural product repurposing; alkaloids; limonoids
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of a previous Special Issue entitled “Multi-Omics Analysis and Application of Plant Natural Products” (https://www.mdpi.com/journal/ijms/special_issues/Omics_Plant_Natural_Products). Omics can systematically scan changes in genes, proteins, and metabolites in vivo, providing an unbiased view of biological processes or drug interventions. Combining biological and chemical big data allows omics to reproduce physical patterns more comprehensively. Therefore, omics is widely used in medical diagnostics, drug repurposing, the active ingredients of traditional herbs, and functional factors in food. The current Special Issue of IJMS aims to reflect applications of omics tools in natural products from plants, herbs, or food materials. The submission of manuscripts focusing on exploring new structures, functions, and mechanisms of natural products using omics is strongly encouraged. We also welcome pioneering research developing new omic methodologies around natural product research.

Dr. Qiang Zhang
Guest Editor

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Keywords

  • omics
  • plant components
  • bioactivity
  • signaling
  • pathway
  • target
  • mechanism

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Published Papers (1 paper)

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Research

16 pages, 4696 KiB  
Article
Toxic Features and Metabolomic Intervention of Glabrene, an Impurity Found in the Pharmaceutical Product of Glabridin
by Xue Li, Haixin Jiang, Dongxue Guo, Wen Huang, Houpu Ren and Qiang Zhang
Int. J. Mol. Sci. 2024, 25(16), 8985; https://doi.org/10.3390/ijms25168985 - 18 Aug 2024
Viewed by 778
Abstract
Glabridin is a widely used product in the cosmetics and pharmaceutical industry, which is generally isolated and purified from Licorice (Glycyrrhiza glabra) extract in industrial production. It has wide clinical applications, but significant toxicity has also been reported. The purity of [...] Read more.
Glabridin is a widely used product in the cosmetics and pharmaceutical industry, which is generally isolated and purified from Licorice (Glycyrrhiza glabra) extract in industrial production. It has wide clinical applications, but significant toxicity has also been reported. The purity of glabridin raw material is generally between 90% and 98%. We have identified a toxic impurity, glabrene, in the industrial product glabridin. Our investigation using an AB wild-type zebrafish toxicity test showed that glabrene has a significant lethal effect with an LC10 of 2.8 μM. Glabrene induced obvious malformation and disrupted cartilage development in zebrafish larvae. Furthermore, the compound significantly reduced larval mobility and caused damage to brain neural tissues. Metabolic pathway analysis and neurotransmitter quantification via ELISA indicated abnormal activation of the phenylalanine metabolic pathway, resulting in elevated dopamine and acetylcholine levels in vivo. These findings provide insights into the potential risks of glabrene contamination and offer a new reference point for enhancing safety measures and quality controls in licorice-derived products. Full article
(This article belongs to the Special Issue Multi-Omics Analysis and Application of Plant Natural Products 2.0)
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