Exploring the Molecular Basis of Cellular Responses to Microgravity-Induced Oxidative Stress
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 1727
Special Issue Editors
2. Center for Advanced Studies and Technology (CAST), University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy
Interests: simulated microgravity; cell metabolism; oxidative stress; cytoskeletal remodeling; cell shape
Special Issues, Collections and Topics in MDPI journals
2. Center for Advanced Studies and Technology (CAST), University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy
Interests: ROS; calcium; live imaging; cardiac muscle; skeletal muscle; simulated microgravity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Microgravity induces significant oxidative stress that profoundly affects cellular function and survival, leading to altered gene expression, metabolic dysfunction, and cellular damage. Understanding the molecular pathways that modulate cellular responses to this stress is crucial, particularly in the context of long-term space missions.
The goal of this Special Issue, “Exploring the Molecular Basis of Cellular Responses to Microgravity-Induced Oxidative Stress”, is to present the most recent research focused on elucidating the cellular and molecular mechanisms triggered by oxidative stress under both real and simulated microgravity conditions. We welcome studies focused on all biological kingdoms—prokaryotes, eukaryotes, animals, and plants—investigating how these cells repair oxidative damage or maintain redox homeostasis in such peculiar environments.
Additionally, this Special Issue aims to highlight innovative strategies to mitigate oxidative damage and propose potential protective approaches that could benefit both space missions and terrestrial applications. Research utilizing advanced technologies, such as genomics, transcriptomics, and proteomics, is highly encouraged, as these methodologies provide comprehensive insights into gene expression, RNA dynamics, and protein responses under microgravity conditions.
We invite both original research articles and comprehensive reviews that will significantly contribute to advancing our understanding of oxidative stress and its impact on biological systems in microgravity.
Dr. Caterina Morabito
Dr. Simone Guarnieri
Guest Editors
Manuscript Submission Information
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Keywords
- microgravity
- reactive oxygen species (ROS)
- oxidative damage
- cellular antioxidant systems
- cell metabolism
- cell responses
- molecular pathways
- simulated microgravity
- protective countermeasures
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