Oxidative Balance and Heart Function: A Physiological Lifelong Challenge
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 11281
Special Issue Editors
Interests: ROS; Calcium; live imaging; cardiac muscle; skeletal muscle
Interests: simulated-microgravity; lymphocytes; oxidative stress; cytoskeletal remodelling; Cell Shape
Special Issue Information
Dear Colleagues,
Free radicals are highly reactive molecules that play a crucial part in different physiological and
physiopathological processes including cell signaling, inflammation and immune defense. In chemical terms, the actions of free radicals can affect the cell physiological response, increasing or decreasing the levels of unstable products able to react with other molecules or acting as physiological process modulators that cause, if not properly balanced, damage to cellular and sub-cellular components.
From this point of view, free radicals and reactive oxygen species (ROS) can be considered not only as "cell toxic species" but also as cell messengers. Thus, they induce oxidative modification in protein, nucleic acid and lipids, acting as second messengers controlling changes in molecular pathways. Emerging evidence demonstrates that ROS, via post-translational modifications, denoted as ‘oxidative eustress’, has a central role in the heart, at the physiological level.
At the physiological nanomolar level, ROS are mediators of signaling through specific protein targets,
which are involved in metabolic regulation to support cardiomyocytes function and adaptation. On the other hand, an excess of ROS is detrimental for cardiac function. In this scenario, the redox balancing in the heart is a direct consequence of ROS and ROS countermeasures, acting together to maintain homeostasis. Alteration of this equilibrium could contribute to the physiological aging of the heart and to the onset of pathological conditions. In addition, the degree of these alterations could be also a consequence of a suboptimal lifestyle or environmental challenges that cause metabolism to be more prone to ROS.
The aim of this Special Issue is to focus on the most recent discoveries on ROS-induced cell
responses influencing cardiac function, and to highlight the different molecular mechanisms, signaling pathways and biological strategies by which cardiomyocytes adapt/react to oxidative stress.
Prof. Dr. Simone Guarnieri
Dr. Caterina Morabito
Guest Editors
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Keywords
- antioxidant
- oxidative stress
- heart
- lifestyle
- environmental challenges
- reactive oxygen species
- aging
- post-translational modifications
- nutrition
- cardiomyocites
- metabolism
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