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Molecular Associations Between Adipose Tissue and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 559

Special Issue Editors


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Guest Editor
1. Galascreen Laboratories, University of Calabria, 87036 Rende, Italy
2. Research Division, Dynamical Business & Science Society, DBSS International SAS, Bogota 110311, Colombia
Interests: nutrition; diet; ketogenic diet; lipedema; biochemistry of nutrition; nutraceuticals; polyphenols; microRNA; epigenetics; sport nutrition; strength training; nutritional supplementation
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Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Magna Grecia, Catanzaro, Italy
Interests: GPCRs; growth factor; microRNAs; insulin secretion; antioxidants

Special Issue Information

Dear Colleagues,

The term adipose tissue is now considered reductive. Instead, we now speak of the adipose organ; this is because it is subject to pathological conditions that limit its functioning and consequently influence the entire organism. We are increasingly seeing how there is a dense network between the adipose organ and all the other organs, the skeletal and cardiac muscles in particular, but also the central nervous system. For this reason, it is essential to understand how this complex interconnection is operated and how it can be influenced by nutrition, food supplements, lifestyle, and drugs. Finally, it would be worth considering the epigenetic features that the adipose organ could have, for example, through miRNA, and the role it plays in the regulation of physiology and pathophysiology.

Dr. Roberto Cannataro
Dr. Erika Cione
Dr. Maria Cristina Caroleo
Guest Editors

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Keywords

  • lipedema
  • adipose tissue
  • adipocyte
  • adipose organ
  • body fat
  • miRNA
  • ketogenic diet

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Published Papers (1 paper)

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Research

22 pages, 2629 KB  
Article
Intermittent Cold Exposure Induces Distinct Proteomic Signatures in White Adipose Tissue of Mice
by Elena Elsukova, Tatiana Zamay, Anna Kichkailo, Andrey Yakunenkov, Dmitry V. Veprintsev, Zoran Minic, Maxim V. Berezovski and Yury Glazyrin
Int. J. Mol. Sci. 2025, 26(16), 7898; https://doi.org/10.3390/ijms26167898 - 15 Aug 2025
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Abstract
Adipose tissue exhibits dynamic metabolic and structural changes in response to environmental stimuli, including temperature fluctuations. While continuous cold exposure has been extensively studied, the molecular effects of prolonged intermittent cold exposure (ICE) remain poorly characterized. Here, we present a proteomic analysis of [...] Read more.
Adipose tissue exhibits dynamic metabolic and structural changes in response to environmental stimuli, including temperature fluctuations. While continuous cold exposure has been extensively studied, the molecular effects of prolonged intermittent cold exposure (ICE) remain poorly characterized. Here, we present a proteomic analysis of inguinal white adipose tissue (IWAT) from mice subjected to a 16-week regimen of short-term daily ICE (6 °C for 6 h, 5 days per week) without compensatory caloric intake. Mass spectrometry identified 1108 proteins, with 140 differentially expressed between experimental and control groups. ICE significantly upregulated mitochondrial proteins associated with lipid and carbohydrate catabolism, the tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and lipogenesis, including LETM1, AIFM1, PHB, PHB2, ACOT2, NDUA9, and ATP5J. These changes reflect enhanced metabolic activity and mitochondrial remodeling. In contrast, proteins linked to oxidative stress, insulin resistance, inflammation, and extracellular matrix remodeling were downregulated, such as HMGB1, FETUA, SERPH1, RPN1, and AOC3. Notably, gamma-synuclein (SYUG), which inhibits lipolysis, was undetectable in ICE-treated samples. Our findings support the hypothesis that ICE promotes thermogenic reprogramming and metabolic rejuvenation in subcutaneous fat through activation of futile cycles and mitochondrial restructuring. This study offers molecular insights into adaptive thermogenesis and presents intermittent cold exposure as a potential strategy to mitigate adipose tissue aging. Full article
(This article belongs to the Special Issue Molecular Associations Between Adipose Tissue and Diseases)
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