Hormone Receptors and Signaling in Breast Cancer, 2nd Edition

Dear Colleagues,

Breast cancer is a serious health problem worldwide, representing the second cause of death through malignancies among women in developed countries. Environmental factors, endogenous and exogenous hormones, as well as physiological and genetic factors, are involved in the pathogenesis of breast cancer.

It is classified into a few major molecular subtypes according to hormone and growth factor receptor expression. Approximately 70% of breast tumors express estrogen receptor α (ERα), most showing hormone dependence and responding to adjuvant endocrine therapies. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) is a signaling pathway involved in cell proliferation, survival, invasion, migration, apoptosis, glucose metabolism, and DNA repair. Aberrations in the PI3K/AKT/mTOR pathway are common in breast cancer. Preclinical data support the notion that these aberrations predict the inhibition of breast cancer by targeted agents.

This Special Issue aims to provide a timely peer-reviewed and open access platform for original research and review articles focused on the latest findings relating to hormone receptor activation in breast cancer progression and metastasis, as well as the applications of this knowledge for disease therapeutics.

Dr. Farzad Pakdel
Guest Editor

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