ijms-logo

Journal Browser

Journal Browser

Molecular Advances in Systemic Lupus Erythematosus

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 2915

Special Issue Editor


E-Mail Website
Guest Editor
Departamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, Mexico
Interests: rhupus syndrome; novel biomarkers in SLE; type I and III interferons in SLE; inflammation in autoimmunity; cardiovascular disease and inflammation

Special Issue Information

Dear Colleagues,

We would like to invite you to contribute a manuscript to he Special Issue of the International Journal of Molecular Sciences on "Molecular Advances in Systemic Lupus Erythematosus".

Systemic lupus erythematosus, a complex autoimmune disease, poses significant challenges to both patients and healthcare professionals worldwide. Through this special edition, we aim to assemble a comprehensive collection of cutting-edge research and insights into the molecular mechanisms underlying lupus pathogenesis, diagnosis, treatment, and management.

Systemic lupus erythematosus stands at the intersection of various disciplines, including rheumatology, immunology, genetics, molecular biology, and clinical medicine. This Special Issue seeks to explore the latest advancements in understanding the intricate molecular pathways contributing to lupus onset and progression. Contributions may encompass but are not limited to the following:

  1. Genetic predisposition and epigenetic modifications in systemic lupus erythematosus susceptibility.
  2. Dysregulation of immune responses and inflammation pathways in systemic lupus erythematosus.
  3. Molecular biomarkers for early diagnosis, disease activity monitoring, and prognosis prediction.
  4. Novel therapeutic targets and strategies, including precision medicine approaches.
  5. Advancements in molecular imaging techniques for systemic lupus erythematosus detection and monitoring.
  6. Molecular mechanisms underlying organ-specific manifestations in systemic lupus erythematosus, such as nephritis, articular involvement, and neuropsychiatric symptoms.
  7. Microbiota and dysbiosis in systemic lupus erythematosus, alongside the abnormal generation of bioactive metabolites affecting both cardiovascular and immune functions.

We invite original research articles, reviews, perspectives, and clinical studies with biomolecular experiments that shed light on the molecular intricacies of SLE and offer potential avenues for improved patient outcomes. Please note that the Special Issue is focused on molecular research, so pure clinical research will not be accepted. However, clinical submissions with biomolecular experiments are welcome.

Dr. Luis M. Amezcua-Guerra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dysregulation of innate and adaptive immune pathways
  • type I and III interferon signaling
  • genetic predisposition and epigenetic modifications
  • role of B cells and autoantibodies
  • inflammasome activation
  • microbiome dysbiosis

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

22 pages, 2749 KiB  
Review
Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus
by Nefertari Sagrero-Fabela, Ramón Chávez-Mireles, Diana Celeste Salazar-Camarena and Claudia Azucena Palafox-Sánchez
Int. J. Mol. Sci. 2024, 25(14), 7726; https://doi.org/10.3390/ijms25147726 - 15 Jul 2024
Cited by 1 | Viewed by 2682
Abstract
Despite advances in understanding systemic lupus erythematosus (SLE), many challenges remain in unraveling the precise mechanisms behind the disease’s development and progression. Recent evidence has questioned the role of programmed cell death protein 1 (PD-1) in suppressing autoreactive CD4+ T cells during [...] Read more.
Despite advances in understanding systemic lupus erythematosus (SLE), many challenges remain in unraveling the precise mechanisms behind the disease’s development and progression. Recent evidence has questioned the role of programmed cell death protein 1 (PD-1) in suppressing autoreactive CD4+ T cells during autoimmune responses. Research has investigated the potential impacts of PD-1 on various CD4+ T-cell subpopulations, including T follicular helper (Tfh) cells, circulating Tfh (cTfh) cells, and T peripheral helper (Tph) cells, all of which exhibit substantial PD-1 expression and are closely related to several autoimmune disorders, including SLE. This review highlights the complex role of PD-1 in autoimmunity and emphasizes the imperative for further research to elucidate its functions during autoreactive T-cell responses. Additionally, we address the potential of PD-1 and its ligands as possible therapeutic targets in SLE. Full article
(This article belongs to the Special Issue Molecular Advances in Systemic Lupus Erythematosus)
Show Figures

Figure 1

Back to TopTop