Chronic Rhinosinusitis: Aetiology, Immunology and Treatment, 3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 25 November 2024 | Viewed by 1830
Special Issue Editor
Interests: mucosal immunity; airway inflammation; epithelial cell biology; eosinophils; fungal infection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issue entitled “Chronic Rhinosinusitis: Aetiology, Immunology and Treatment 2.0” (https://www.mdpi.com/journal/ijms/special_issues/EW08YBRXM7).
Chronic rhinosinusitis (CRS) is one of the most common chronic diseases. However, the pathophysiology of CRS is not fully understood, the treatment options are limited, and it features heterogeneous disease groups.
CRS was once considered an infectious disease, with focus placed on the identification of the pathogenic microbial organisms. However, recent studies have suggested that CRS may be related to immune-mediated diseases, the involvement of which may cause the exacerbation of local inflammatory responses. CRS is classified as eosinophilic or non-eosinophilic CRS based on the dominant inflammatory cell types. CRS can also be divided into Th1-, Th2-, and Th17-dominant CRS based on the presence of lymphocyte effector cells in the sinonasal mucosa. Many researchers have attempted to determine the pathogenesis of CRS by identifying key chemical mediators or transcription factors and using various animal models. In this regard, many efforts are being made to elucidate the immunopathologic mechanism of CRS. Because CRS is a sinonasal mucosal inflammatory disease, surgical treatment options are limited. Therefore, biologics are garnering attention as a novel therapeutic strategy for CRS.
This Special Issue will focus on advances in the field of mucosal immunity and their impact on our understanding of the development of CRS and the immunologic effects of biologics for the treatment of CRS. IJMS is a journal of molecular science, so pure clinical studies are not suitable; however, biomolecular experimental studies are welcome.
Dr. Seung-Heon Shin
Guest Editor
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Keywords
- innate immunity
- adaptive immunity
- protease
- cytokine
- inflammation
- epithelial cells
- fibroblasts
- eosinophils
- lymphocytes
- biologics
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