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Molecular Research of Ocular Pathologies, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 822

Special Issue Editors


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Guest Editor
Faculty of Optics and Optometry and Director of Ocupharm Group Research, Universidad Complutense de Madrid, 28037 Madrid, Spain
Interests: dry eye; myopia; contact lenses; ocular biochemistry; glaucoma
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Ocupharm Group Research, Faculty of Optics and Optometry, Complutense University, 28037 Madrid, Spain
Interests: nucleotides; purinergic signaling; melatonin; glaucoma; dry eye; contact lenses
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue entitled “Molecular Research of Ocular Pathology”.

The eye is a very complex organ with several different tissues and structures connecting them. The eye’s function is to take the light from the environment, transform it into electrical signals, and send them to the brain for creating images. Molecular research regarding the eye is currently critical in better understanding the mechanisms of ocular pathologies and, in turn, in creating better diagnosis tools as new biomarkers or improving the treatment efficacy via the use of new molecules, which may reach the tissue target much easier. This Special Issue aims to present original research and review articles that summarize state-of-the-art developments, that attempt to answer some crucial questions, and that cover current aspects that focus on diagnosis, treatment, or biochemistry pathways in ocular pathologies, such as dry eye, glaucoma, or retinal diseases.

On behalf of the International Journal of Molecular Science editorial office, we invite you to contribute your review articles and research papers concerning “Molecular research in ocular pathologies” for peer review and possible publication.

Prof. Dr. Gonzalo Carracedo
Dr. Alba Martín-Gil
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ocular pathologies
  • dry eye
  • glaucoma
  • retinal diseases
  • oxidative stress
  • inflammation
  • molecular treatments
  • molecular biomarkers
 

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Published Papers (1 paper)

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Research

15 pages, 2433 KiB  
Article
FABP5 Is a Possible Factor for the Maintenance of Functions of Human Non-Pigmented Ciliary Epithelium Cells
by Megumi Higashide, Megumi Watanabe, Tatsuya Sato, Araya Umetsu, Nami Nishikiori, Toshifumi Ogawa, Masato Furuhashi and Hiroshi Ohguro
Int. J. Mol. Sci. 2024, 25(17), 9285; https://doi.org/10.3390/ijms25179285 - 27 Aug 2024
Viewed by 472
Abstract
To elucidate the possible biological roles of fatty acid-binding protein 5 (FABP5) in the intraocular environment, the cells from which FABP5 originates were determined by using four different intraocular tissue-derived cell types including human non-pigmented ciliary epithelium (HNPCE) cells, retinoblastoma (RB) cells, adult [...] Read more.
To elucidate the possible biological roles of fatty acid-binding protein 5 (FABP5) in the intraocular environment, the cells from which FABP5 originates were determined by using four different intraocular tissue-derived cell types including human non-pigmented ciliary epithelium (HNPCE) cells, retinoblastoma (RB) cells, adult retinal pigment epithelial19 (ARPE19) cells and human ocular choroidal fibroblast (HOCF) cell lines, and the effects of FABP ligand 6, a specific inhibitor for FABP5 and FABP7 were analyzed by RNA sequencing and seahorse cellular metabolic measurements. Among these four different cell types, qPCR analysis showed that FABP5 was most prominently expressed in HNPCE cells, in which no mRNA expression of FABP7 was detected. In RNA sequencing analysis, 166 markedly up-regulated and 198 markedly down-regulated differentially expressed genes (DEGs) were detected between non-treated cells and cells treated with FABP ligand 6. IPA analysis of these DEGs suggested that FABP5 may be involved in essential roles required for cell development, cell survival and cell homeostasis. In support of this possibility, both mitochondrial and glycolytic functions of HNPCE cells, in which mRNA expression of FABP5, but not that of FABP7, was detected, were shown by using a Seahorse XFe96 Bioanalyzer to be dramatically suppressed by FABP ligand 6-induced inhibition of the activity of FABP5. Furthermore, in IPA upstream analysis, various unfolded protein response (UPR)-related factors were identified as upstream and causal network master regulators. Analysis by qPCR analysis showed significant upregulation of the mRNA expression of most of UPR-related factors and aquaporin1 (AQP1). The findings in this study suggest that HNPCE is one of intraocular cells producing FABP5 and may be involved in the maintenance of UPR and AQP1-related functions of HNPCE. Full article
(This article belongs to the Special Issue Molecular Research of Ocular Pathologies, 2nd Edition)
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