Roles of the Immune System in Neuropathic Pain
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 8963
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neuropathic pain is caused by lesions or diseases of the somatosensory system and is a major public health issue around the world. It is characterized by increased responses to nociceptive stimuli (hyperalgesia), unpleasant and abnormal sensations (dysesthesia), and pain in response to light tactile stimuli (allodynia). Studies show that neuropathic pain involves a series of pathophysiologic events when the nerve is damaged, including neuronal hyperexcitability, changes in perineuronal homeostasis, and neurogenic inflammation.
Although the treatment for neuropathic pain remains a great challenge, progress has been made in identifying key molecules and their roles in pain modulation and processing. Recent developments in the investigation of neurological disorders have led to an enhanced focus on the role of the immune response and the interaction between the immune system and the nervous system.
The main purpose of this Special Issue is to collect original research articles, reviews, and perspectives to further our understanding of the pathological immune responses and the role of the immune system in neuropathic pain, which can be used as therapeutic targets for pain treatment. Both animal models and human studies are welcome.
Dr. Wei-Zen Sun
Guest Editor
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Keywords
- opioid
- macrophage
- spared nerve injury
- acupuncture
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