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A Commemorative Issue in Honor of József Szejtli: Advances in Cyclodextrin Chemistry and Its Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 693

Special Issue Editors


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Guest Editor
CycloLab Cyclodextrin Research & Development Laboratory, Ltd., Budapest, Hungary
Interests: cyclodextrin polymers; environmental applications; analysis of cyclodextrins and complexes

E-Mail Website
Guest Editor
CycloLab Cyclodextrin Research & Development Laboratory, Ltd., Budapest, Hungary
Interests: cyclodextrins in drug delivery; cyclodextrins as active ingredients; applications in food; cosmetics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Chemistry, School of Science, Universidad de Navarra, 31080 Pamplona, Spain
2. SUMBET (Supramolecular Materials for Biomedical and Environmental Technologies), Universidad de Navarra, C/ Irunlarrea 1, 31080 Pamplona, Spain
3. BIOMA (Instituto de Biodiversidad y Medioambiente), Universidad de Navarra, C/ Irunlarrea 1, 31080 Pamplona, Spain
Interests: supramolecular chemistry; cyclodextrins; colloids; polymers; hydrogels; nanocomposites; scattering methods
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The papers in this Special Issue are derived from works presented at the 7th European Cyclodextrin Conference on 5–8 September 2023 in Budapest. Manuscripts in various fields of cyclodextrin chemistry and applications are its scope, including the latest results in cyclodextrin production and enzymology, synthesis and the characterization of novel cyclodextrin derivatives, modern tools for studying complexation, nanotechnology, self-assembling systems, drug delivery, gene/RNA delivery, therapeutic and diagnostic applications of pure cyclodextrins and their complexes, uses in food, cosmetic and other industries, as well as environmental technologies.

This Special Issue is dedicated to Professor József Szejtli on the 90th anniversary of his birth in 1933. Professor Szejtli played a fundamental role in developing cyclodextrins by devoting his life to these cyclic carbohydrates. Professor Szejtli is internationally recognized for his outstanding contributions to various fields in cyclodextrin science. He is often mentioned as the “Godfather of Cyclodextrins.” The EuroCD_2023 conference follows the traditions started by Professor Szejtli in 1981: the first International Cyclodextrin Symposium in Budapest.

The International Journal of Molecular Sciences is an international, peer-reviewed, open-access journal providing an advanced forum for biochemistry, molecular and cell biology, molecular biophysics, molecular medicine, and all aspects of molecular research in chemistry. It has an impact factor of 6.208 and is ranked JCR - Q1 in Biochemistry & Molecular Biology. IJMS has offered a special publication fee: a 450 CHF discount for all the participants of the EuroCD2023 conference.

Manuscripts will be accepted from 1st August to 30th November 2023.

Dr. Éva Fenyvesi
Dr. Lajos Szente
Prof. Dr. Gustavo Gonzalez-Gaitano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Published Papers (1 paper)

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16 pages, 4152 KiB  
Article
Advantages of Induced Circular Dichroism Spectroscopy for Qualitative and Quantitative Analysis of Solution-Phase Cyclodextrin Host–Guest Complexes
by Márta Kraszni, Balázs Balogh, István Mándity and Péter Horváth
Int. J. Mol. Sci. 2024, 25(1), 412; https://doi.org/10.3390/ijms25010412 - 28 Dec 2023
Viewed by 731
Abstract
The presence of a chiral or chirally perturbed chromophore in the molecule under investigation is a fundamental requirement for the appearance of a circular dichroism (CD) spectrum. For native and for most of the substituted cyclodextrins, this condition is not applicable, because although [...] Read more.
The presence of a chiral or chirally perturbed chromophore in the molecule under investigation is a fundamental requirement for the appearance of a circular dichroism (CD) spectrum. For native and for most of the substituted cyclodextrins, this condition is not applicable, because although chiral, cyclodextrins lack a chromophore group and therefore have no characteristic CD spectra over 220 nm. The reason this method can be used is that if the guest molecule has a chromophore group and this is in the right proximity to the cyclodextrin, it becomes chirally perturbed. As a result, the complex will now provide a CD signal, and this phenomenon is called induced circular dichroism (ICD). The appearance of the ICD spectrum is clear evidence of the formation of the complex, and the spectral sign and intensity is a good predictor of the structure of the complex. By varying the concentration of cyclodextrin, the ICD signal changes, resulting in a saturation curve, and from these data, the stability constant can be calculated for a 1:1 complex. This article compares ICD and NMR spectroscopic and molecular modeling results of cyclodextrin complexes of four model compounds: nimesulide, fenbufen, fenoprofen, and bifonazole. The results obtained by the different methods show good agreement, and the structures estimated from the ICD spectra are supported by NMR data and molecular modeling. Full article
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