Advances in the Nanoparticles-Based Drug Delivery in Cancer Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 21
Special Issue Editor
Interests: biomaterials; tissue engineering; drug delivery; photothermal therapy; controlled drug release; nanomaterials
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nanoparticle-based drug delivery systems changed the landscape of cancer therapy by improving the precision and efficacy of treatments. These nanosized therapeutics use engineered nanoparticles, made from materials such as lipids, polymers, and metals, to transport anticancer therapeutics, such as drugs, genetic material, or immunotherapeutic agents, directly to the tumor tissue. This targeted approach minimizes damage to healthy tissues and reduces side effects when compared to conventional chemotherapy.
One significant advance is the development of “smart nanomaterials”. One example is the stimuli-responsive nanoparticles, which release their payload in response to specific conditions, such as pH or temperature changes within the tumor microenvironment. Additionally, nanoparticles can be designed to evade the immune system, prolonging circulation time and enhancing drug accumulation in cancerous tissues. The surface modification of nanoparticles can also be explored to attach targeting moieties, such as ligands or antibodies, that further enhance nanoparticles’ selectivity, allowing them to specifically recognize and interact with cancer cells. Another breakthrough is the combination of nanoparticles with imaging agents, enabling the real-time monitoring of drug delivery and treatment progress. These advances offer a more comprehensive and personalized approach to cancer treatment, potentially leading to better outcomes and reduced drug resistance. As research continues, nanoparticle-based drug delivery is expected to play a pivotal role in the future of cancer therapy. Molecular-level research that provides novel insights and discoveries on these compelling subjects is encouraged to be submitted. Both original research papers and review articles are welcome.
Dr. André F. Moreira
Guest Editor
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Keywords
- nanoparticle-based drug delivery
- stimuli responsive
- cancer targeting
- theragnostic nanoparticles
- protein corona
- combinatorial drug therapies
- tumor penetration
- cancer cells uptake
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