Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
The Research about Cytomegalovirus (CMV)
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

The Research about Cytomegalovirus (CMV)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (12 January 2024) | Viewed by 7628

Special Issue Editor

Dr. Pilar Pérez Romero

E-Mail Website
Guest Editor
Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain
Interests: cytomegalovirus; CMV genome; T-cell immune response; neutralizing antibodies; vaccine design
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cytomegalovirus (CMV) infection continues to be an important cause of morbidity, especially in individuals with an immature or dysfunctional immune system who develop complications associated with the infection, resulting in an important public health issue. In addition to the number of groups trying to understand the dynamics of CMV infection, the complex interaction between CMV and the immune system, the absence of an animal model that is able to reproduce the human physiology associated with CMV, and the lack of information on many of the potential proteins encoded by the CMV genome have limited our knowledge about virus–host interactions.

This Special Issue will focus on basic science and translational research to obtain complete comprehension of the CMV genome, the factors that contribute to the CMV virus–cell interaction, and tropism and implications for vaccine design.

Dr. Pilar Pérez Romero
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

 

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

13 pages, 627 KiB  
Article
Cytomegalovirus in Adenoma and Carcinoma Lesions: Detecting Mono-Infection and Co-Infection in Salivary Glands
by Ana Carolina Silva Guimarães, Jéssica Vasques Raposo Vedovi, Camilla Rodrigues de Almeida Ribeiro, Katrini Guidolini Martinelli, Marcelo Pelajo Machado, Pedro Paulo de Abreu Manso, Barbara Cristina Euzebio Pereira Dias de Oliveira, Mariana Lobo Bergamini, Catharina Simioni de Rosa, Tania Regina Tozetto-Mendoza, Ana Carolina Mamana Fernandes de Souza, Marília Trierveiler Martins, Paulo Henrique Braz-Silva and Vanessa Salete de Paula
Int. J. Mol. Sci. 2024, 25(14), 7502; https://doi.org/10.3390/ijms25147502 - 9 Jul 2024
Viewed by 1054
Abstract
Salivary glands’ neoplasms are hard to diagnose and present a complex etiology. However, several viruses have been detected in these neoplasms, such as HCMV, which can play a role in certain cancers through oncomodulation. The co-infections between HCMV with betaherpesviruses (HHV-6 and HHV-7) [...] Read more.
Salivary glands’ neoplasms are hard to diagnose and present a complex etiology. However, several viruses have been detected in these neoplasms, such as HCMV, which can play a role in certain cancers through oncomodulation. The co-infections between HCMV with betaherpesviruses (HHV-6 and HHV-7) and polyomaviruses (JCV and BKV) has been investigated. The aim of the current study is to describe the frequency of HCMV and co-infections in patients presenting neoplastic and non-neoplastic lesions, including in the salivary gland. Multiplex quantitative polymerase chain reaction was used for betaherpesvirus and polyomavirus quantification purposes after DNA extraction. In total, 50.7% of the 67 analyzed samples were mucocele, 40.3% were adenoma pleomorphic, and 8.9% were mucoepidermoid carcinoma. Overall, 20.9% of samples presented triple-infections with HCMV/HHV-6/HHV-7, whereas 9.0% were co-infections with HCMV/HHV-6 and HCMV/HHV-7. The largest number of co-infections was detected in pleomorphic adenoma cases. All samples tested negative for polyomaviruses, such as BKV and JCV. It was possible to conclude that HCMV can be abundant in salivary gland lesions. A high viral load can be useful to help better understand the etiological role played by viruses in these lesions. A lack of JCV and BKV in the samples analyzed herein does not rule out the involvement of these viruses in one or more salivary gland lesion subtypes. Full article
(This article belongs to the Special Issue The Research about Cytomegalovirus (CMV))
►▼ Show Figures

Figure 1

9 pages, 7417 KiB  
Communication
The Auditory Pathway in Congenitally Cytomegalovirus-Infected Human Fetuses
by Liliana Gabrielli, Maria Paola Bonasoni, Giulia Piccirilli, Evangelia Petrisli, Simona Venturoli, Alessia Cantiani, Matteo Pavoni, Concetta Marsico, Maria Grazia Capretti, Giuliana Simonazzi and Tiziana Lazzarotto
Int. J. Mol. Sci. 2024, 25(5), 2636; https://doi.org/10.3390/ijms25052636 - 24 Feb 2024
Cited by 1 | Viewed by 1145
Abstract
Congenital cytomegalovirus (CMV) infection is the main cause of non-hereditary sensorineural hearing loss (SNHL). In order to shed light on SNHL pathophysiology, we examined the auditory pathway in CMV-infected fetuses; the temporal lobe, in particular the auditory cortex, and the inner ear. We [...] Read more.
Congenital cytomegalovirus (CMV) infection is the main cause of non-hereditary sensorineural hearing loss (SNHL). In order to shed light on SNHL pathophysiology, we examined the auditory pathway in CMV-infected fetuses; the temporal lobe, in particular the auditory cortex, and the inner ear. We investigated both inner ears and temporal lobes of 20 human CMV-infected fetuses at 21 weeks of gestation. As a negative group, five fetuses from spontaneous miscarriages without CMV infection were studied. Inner ears and temporal lobes were histologically examined, immunohistochemistry for CMV and CMV-PCR were performed. On the auditory cortex, we evaluated the local microglial reaction to the infection. CMV-positive cells were found in 14/20 brains and the damage was classified as severe, moderate, or mild, according to histological features. Fetuses with severe brain damage had a statistically higher temporal lobe viral load and a higher number of activated microglial cells in the auditory cortex compared to fetuses with mild brain damage (p: 0.01; p: 0.01). In the inner ears, the marginal cells of the stria vascularis were the most CMV positive. In our study, CMV affected the auditory pathway, suggesting a tropism for this route. In addition, in the auditory cortex, microglial activation may favor further tissue damage contributing to hearing loss. Full article
(This article belongs to the Special Issue The Research about Cytomegalovirus (CMV))
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

27 pages, 2709 KiB  
Review
Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease
by Ludmila Müller and Svetlana Di Benedetto
Int. J. Mol. Sci. 2024, 25(2), 753; https://doi.org/10.3390/ijms25020753 - 6 Jan 2024
Cited by 4 | Viewed by 3696
Abstract
Aging induces numerous physiological alterations, with immunosenescence emerging as a pivotal factor. This phenomenon has attracted both researchers and clinicians, prompting profound questions about its implications for health and disease. Among the contributing factors, one intriguing actor in this complex interplay is human [...] Read more.
Aging induces numerous physiological alterations, with immunosenescence emerging as a pivotal factor. This phenomenon has attracted both researchers and clinicians, prompting profound questions about its implications for health and disease. Among the contributing factors, one intriguing actor in this complex interplay is human cytomegalovirus (CMV), a member of the herpesvirus family. Latent CMV infection exerts a profound influence on the aging immune system, potentially contributing to age-related diseases. This review delves into the intricate relationship between immunosenescence and CMV, revealing how chronic viral infection impacts the aging immune landscape. We explore the mechanisms through which CMV can impact both the composition and functionality of immune cell populations and induce shifts in inflammatory profiles with aging. Moreover, we examine the potential role of CMV in pathologies such as cardiovascular diseases, cancer, neurodegenerative disorders, COVID-19, and Long COVID. This review underlines the importance of understanding the complex interplay between immunosenescence and CMV. It offers insights into the pathophysiology of aging and age-associated diseases, as well as COVID-19 outcomes among the elderly. By unraveling the connections between immunosenescence and CMV, we gain a deeper understanding of aging’s remarkable journey and the profound role that viral infections play in transforming the human immune system. Full article
(This article belongs to the Special Issue The Research about Cytomegalovirus (CMV))
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

13 pages, 2409 KiB  
Brief Report
Re-Analysis of the Widely Used Recombinant Murine Cytomegalovirus MCMV-m157luc Derived from the Bacmid pSM3fr Confirms Its Hybrid Nature
by Arne Cordsmeier, Christopher Bednar, Sabrina Kübel, Larissa Bauer and Armin Ensser
Int. J. Mol. Sci. 2023, 24(18), 14102; https://doi.org/10.3390/ijms241814102 - 14 Sep 2023
Cited by 1 | Viewed by 1002
Abstract
Murine cytomegalovirus (MCMV), and, in particular, recombinant virus derived from MCMV-bacmid pSM3fr, is widely used as the small animal infection model for human cytomegalovirus (HCMV). We sequenced the complete genomes of MCMV strains and recombinants for quality control. However, we noticed deviances from [...] Read more.
Murine cytomegalovirus (MCMV), and, in particular, recombinant virus derived from MCMV-bacmid pSM3fr, is widely used as the small animal infection model for human cytomegalovirus (HCMV). We sequenced the complete genomes of MCMV strains and recombinants for quality control. However, we noticed deviances from the deposited reference sequences of MCMV-bacmid pSM3fr. This prompted us to re-analyze pSM3fr and reannotate the reference sequence, as well as that for the commonly used MCMV-m157luc reporter virus. A correct reference sequence for this frequently used pSM3fr, containing a repaired version of m129 (MCK-2) and the luciferase gene instead of ORF m157, was constructed. The new reference also contains the original bacmid sequence, and it has a hybrid origin from MCMV strains Smith and K181. Full article
(This article belongs to the Special Issue The Research about Cytomegalovirus (CMV))
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop