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Nanoformulations for the Treatment of Inflammation and Metabolic Disorders
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Nanoformulations for the Treatment of Inflammation and Metabolic Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 4136

Special Issue Editor

Prof. Dr. Sergio Acín Martínez

E-Mail Website
Guest Editor
Department of Physiology and Biochemistry, Faculty of Medicine, University of Antioquia, Medellín 050010, Antioquia, Colombia
Interests: natural products; obesity; diabetes; metabolism; nanomolecules
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic disorders are a cluster of conditions that increase the risk of stroke, heart disease, hypertension, dyslipidemia, and type 2 diabetes. Developing effectively therapeutic and preventive measures for these multifactorial metabolic diseases has so far been challenging.

There has been growing interest in natural molecules and synthetic analogs as alternative therapeutical drugs for common chemical therapeutics regarding their limited side effects and ease of access. However, common problems for these compounds are their low solubility and bioavailability. A novel approach is to design nanoformulations of these molecules with developed pharmacodynamics and pharmacokinecs to increase their solubility and bioavailability and promisingly improve their efficacy.

This Special Issue addresses molecular and mechanistic research on nanosized drug carriers, and we invite researchers to contribute original research articles and reviews focused on different nanotechnology-based strategies of natural molecules and synthetic analogs for the treatment of metabolic disorders.

Topics of interest include but are not limited to the following:

  • Obesity;
  • Diabetes;
  • Insulin resistance;
  • Inflammation;
  • Dyslipidemia;
  • Disorders of protein metabolism.

This Special Issue is supervised by Dr. Sergio Acín Martínez and assisted by our Topical Advisory Panel Member, Dr. Norman Balcazar Morales (University of Antioquia).

Prof. Dr. Sergio Acín Martínez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (2 papers)

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16 pages, 10047 KiB  
Article
Pentacyclic Triterpenes from Olive Leaves Formulated in Microemulsion: Characterization and Role in De Novo Lipogenesis in HepG2 Cells
by Marzia Vasarri, Donatella Degl’Innocenti, Laura Albonetti, Anna Rita Bilia and Maria Camilla Bergonzi
Int. J. Mol. Sci. 2023, 24(15), 12113; https://doi.org/10.3390/ijms241512113 - 28 Jul 2023
Cited by 4 | Viewed by 1391
Abstract
Olea europaea L. leaves contain a wide variety of pentacyclic triterpenes (TTPs). TTPs exhibit many pharmacological activities, including antihyperlipidemic effects. Metabolic alterations, such as dyslipidemia, are an established risk factor for hepatocellular carcinoma (HCC). Therefore, the use of TTPs in the adjunctive treatment [...] Read more.
Olea europaea L. leaves contain a wide variety of pentacyclic triterpenes (TTPs). TTPs exhibit many pharmacological activities, including antihyperlipidemic effects. Metabolic alterations, such as dyslipidemia, are an established risk factor for hepatocellular carcinoma (HCC). Therefore, the use of TTPs in the adjunctive treatment of HCC has been proposed as a possible method for the management of HCC. However, TTPs are characterized by poor water solubility, permeability, and bioavailability. In this work, a microemulsion (ME) loading a TTP-enriched extract (EXT) was developed, to overcome these limits and obtain a formulation for oral administration. The extract-loaded microemulsion (ME-EXT) was fully characterized, assessing its chemical and physical parameters and release characteristics, and the stability was evaluated for two months of storage at 4 °C and 25 °C. PAMPA (parallel artificial membrane permeability assay) was used to evaluate the influence of the formulation on the intestinal passive permeability of the TTPs across an artificial membrane. Furthermore, human hepatocarcinoma (HepG2) cells were used as a cellular model to evaluate the effect of EXT and ME-EXT on de novo lipogenesis induced by elevated glucose levels. The effect was evaluated by detecting fatty acid synthase expression levels and intracellular lipid accumulation. ME-EXT resulted as homogeneous dispersed-phase droplets, with significantly increased EXT aqueous solubility. Physical and chemical analyses showed the high stability of the formulation over 2 months. The formulation realized a prolonged release of TTPs, and permeation studies demonstrated that the formulation improved their passive permeability. Furthermore, the EXT reduced the lipid accumulation in HepG2 cells by inhibiting de novo lipogenesis, and the ME-EXT formulation enhanced the inhibitory activity of EXT on intracellular lipid accumulation. Full article
(This article belongs to the Special Issue Nanoformulations for the Treatment of Inflammation and Metabolic Disorders)
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13 pages, 370 KiB  
Perspective
The Use of Metallic Nanoparticles in Wound Healing: New Perspectives
by Carolini Mendes, Anand Thirupathi, Maria E. A. B. Corrêa, Yaodong Gu and Paulo C. L. Silveira
Int. J. Mol. Sci. 2022, 23(23), 15376; https://doi.org/10.3390/ijms232315376 - 6 Dec 2022
Cited by 20 | Viewed by 2333
Abstract
Chronic wounds represent a challenge for the health area, as they directly impact patients’ quality of life and represent a threat to public health and the global economy due to their high cost of treatment. Alternative strategies must be developed for cost-effective and [...] Read more.
Chronic wounds represent a challenge for the health area, as they directly impact patients’ quality of life and represent a threat to public health and the global economy due to their high cost of treatment. Alternative strategies must be developed for cost-effective and targeted treatment. In this scenario, the emerging field of nanobiotechnology may provide an alternative platform to develop new therapeutic agents for the chronic wound healing process. This manuscript aims to demonstrate that the application of metallic nanoparticles (gold, silver, copper, and zinc oxide) opened a new chapter in the treatment of wounds, as they have different properties such as drug delivery, antimicrobial activity, and healing acceleration. Furthermore, metallic nanoparticles (NPs) produced through green synthesis ensure less toxicity in biological tissues, and greater safety of applicability, other than adding the effects of NPs with those of extracts. Full article
(This article belongs to the Special Issue Nanoformulations for the Treatment of Inflammation and Metabolic Disorders)
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