Research on the Amyloid in Alzheimer’s Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2664
Special Issue Editor
Special Issue Information
Dear Colleagues,
Amyloid cascade is still considered as one of the main causes of Alzheimer’s disease (AD). However, the production, transportation, and metabolism of amyloids yields a variety of measurement results. During measuring, different sample storage, various commercial kits for detection, and other factors can affect results. These expected and unexpected factors make the measured amyloid level more difficult to interpret with regard to its medical significance.
All expected biomarkers can explain or reflect medical status, and thus extend or maximize medical benefits. Several studies found that the level amyloids in cerebro-spinal fluid (CSF) can reflect the cognitive or global status of AD, but these findings are not consistent throughout the plasma level of amyloids. Due to the different lengths of amyloid peptides caused by different numbers of amino acids (42, 40, 38, etc.) and various compositions of peptides, monomers, dimers, or oligomers, the targets of measurements with their complicated mechanisms and associations must be determined, especially regarding their medical significance. We encourage original research manuscripts that focus on these issues to be submitted to this Special Issue.
Prof. Dr. Yuan-Han Yang
Guest Editor
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Keywords
- amyloids
- Alzheimer’s disease
- oligomer
- cerebro-spinal fluid
- plasma
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