Mechanisms and Implications of Traumatic Brain Injury and Neuroinflammation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 2615
Special Issue Editor
Interests: post-traumatic stress disorder; substance use disorders; traumatic brain injury; major depression; opioids; ketamine; psychostimulants; neuroinflammation; synaptic plasticity; hypothalamic-pituitary-adrenal (HPA) axis
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Special Issue Information
Dear Colleagues,
Traumatic brain injury (TBI) is a leading cause of death and disability in the world. Although certain individuals recover from TBI, a significant portion of individuals will suffer from long-lasting adverse effects such as physical, cognitive, emotional, social, and behavioural deficits. The TBI consists of primary injury (effects directly tied to the mechanical forces at the moment of impact) and secondary injury (biochemical processes occurring in the hours or days following primary injury). The consequences of primary injury are generally regarded as irreversible, but secondary injury, such as increased neuroinflammation, may provide a target for TBI treatment. Neuroinflammation involves the activation of glial cells (e.g., microglia and astrocytes), the release of inflammatory cytokines and chemokines in the brain, and the subsequent recruitment of peripheral immune cells. Microglia, the primary immune cells in the brain, are critically important in neuroinflammation and serve various roles such as initiating neuroimmune responses, clearing cellular debris, and releasing numerous substances. Microglia can be activated into either a pro-damage state with harmful effects such as the release of neurotoxic and pro-inflammatory substances or a pro-repair state with beneficial effects such as the clearing of cellular debris and the release of neurotrophic factors and anti-inflammatory cytokines, depending on the injury severity and neuroenvironmental factors.
We therefore invite academic, non-profit, and industrial investigators working in the fields of TBI to submit original research articles or reviews describing and discussing the mechanisms and implications of TBI and neuroinflammation to progress basic and clinical sciences related to TBI.
Potential topics include, but are not limited to:
- The molecular and biological mechanisms of TBI and neuroinflammation;
- Biomarkers, including advanced neuroimaging, biosensors, and high-throughput approaches;
- Novel pharmacological and cognitive/behavioural interventions and treatment strategies;
- Translational research to bridge the gap between preclinical and clinical studies;
- The comorbidity of TBI, neuroinflammation, and psychiatric disorders;
- Novel, automated, and unbiased data analysis strategy using machine learning and artificial intelligence technology.
Dr. Kwang Choi
Guest Editor
Manuscript Submission Information
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Keywords
- traumatic brain injury
- head trauma
- neuroinflammation
- secondary injury
- microglia
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