Molecular Advances and Perspectives in Multiple Sclerosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 December 2024 | Viewed by 718
Special Issue Editors
Interests: multiple sclerosis; cognition; EBV; CSF
Interests: experimental autoimmune encephalomielitis; immunometabolism; glial cells; brain barriers; CSF; lipocalin 2
Special Issue Information
Dear Colleagues,
Multiple sclerosis is an auto-immune disease affecting the central nervous system that has both demyelinating and neurodegeneration components. Despite the availability of high efficacy treatments, the pathophysiology of the disease remains poorly understood and many patients still experience disability progression in the long term. In recent years, there have been many new insights into the triggers of the disease (with a focus on Epstein–Barr virus infection) and the drivers of chronic inflammation and degeneration (including iron accumulation, microglia and astrocyte activation and ectopic lymphoid follicle formation), which will shape our understanding of the disease and are already driving the development of novel therapeutic approaches. In addition, although there is evidence for remyelination in patients, strategies to promote it in patients are mostly lacking, probably due to our incomplete knowledge of its mechanisms.
In this Special Issue, we will try to fill these knowledge gaps, publishing research addressing the molecular mechanisms underlying the different aspects of inflammation, degeneration and repair in multiple sclerosis.
Dr. Joao Jose Cerqueira
Dr. Fernanda Marques
Guest Editors
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Keywords
- astrocytes
- axonal transection
- demyelination
- EBV
- immunometabolism
- insulin signaling
- iron
- lymphotoxin
- microglia
- mitochondria
- neurodegeneration
- oligodendrocytes
- remyelination
- brain barriers
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