Molecular Insights into Migraines
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 December 2024 | Viewed by 95
Special Issue Editors
Interests: DNA; RNA; gene expression; cancer; AMD; epigenetics; stem cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although migraine is one of the leading causes of disability worldwide, it is still an underdiagnosed and undertreated disease, which is a consequence of incomplete knowledge of migraine pathogenesis. One of the main reasons for that is restrictive access to the human target material and the limited value of experimental animals to model human migraine. Sensitization of the trigeminovascular system and cortical hyperexcitability are essential mechanisms in migraine pathogenesis, but their molecular basis is unclear. The mechanisms of trigeminal afferent activation by cortical spreading depolarization/depression may be crucial for determining the role of aura in migraine pathogenesis. The development of neuroimaging and the use of induced pluripotent stem cells derived from migraine patients in conjunction with next-generation omics create exceptional opportunities to reveal key molecular players in migraine pathogenesis and develop more effective therapeutic strategies by identifying new drug targets. Therefore, basic research on the molecular interactions in migraine is needed to closely examine the molecular mechanisms of migraine pathogenesis and improve its diagnostic and therapeutic strategies. This Special Issue welcomes original papers and review articles addressing one or several of the above issues or the topics mentioned in the keywords listed below.
Prof. Dr. Janusz Blasiak
Dr. Michał Fila
Guest Editors
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Keywords
- genetics and epigenetics of migraines
- connections between the nuclear and mitochondrial genomes in migraines
- omics in migraine studies
- stem cells in migraine studies
- molecular mediators of nociceptive signaling in migraines
- cortical spreading depolarization/depression
- molecular aspects of metabolic flux in migraines
- programmed cellular death in migraines
- migraine as a channelopathy
- molecular interactions of CGRP
- proteostasis in migraines
- perspective of gene editing in migraines
- molecular basis of migraine triggers
- reactive oxygen and nitrogen species in migraines
- systemic molecular markers of migraines
- molecular aspects of sex dimorphism in migraines
- laboratory and in silico models of molecular interactions in migraines
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