Molecular and Clinical Aspects of Migraine and Its Comorbidities: Epilepsy, Stroke, and Restless Leg Syndrome

Dear Colleagues,

Although migraines are one of the leading causes of disability worldwide, they are still an underdiagnosed and undertreated disease, which is a consequence of the incomplete knowledge of migraine pathogenesis. One of the main reasons for that is the restrictive access to human target material and the limited value of experimental animals to model human migraines. Sensitization of the trigeminovascular system and cortical hyperexcitability are essential mechanisms in migraine pathogenesis, but their molecular basis remains unclear. Migraines are frequently associated with comorbidities such as mental disorders, cardiovascular disease, epilepsy, stroke, restless leg syndrome, among others. In many of these comorbidities, it is not clear whether there is a cause–effect relationship or if they are merely associated with migraines. This Special Issue focuses on migraines and their frequent comorbidities, including epilepsy, stroke, and restless leg syndrome. We welcome original and review papers not only investigating the coexistence of migraines with epilepsy, stroke, and restless leg syndrome but also exploring these three syndromes to provide information on their potential links with migraines. Both experimental and clinical research work are welcome.

Prof. Dr. Janusz Blasiak
Dr. Michał Fila
Guest Editors

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