Bilirubin: Health Challenges and Opportunities
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 15 December 2024 | Viewed by 330
Special Issue Editor
Interests: neuroinflammation; homocysteine in neurology
Special Issue Information
Dear Colleagues,
For a long time now, bilirubin has been considered more than a mere waste metabolite of hemoglobin. Bilirubin is a hormone, a regulator of various signaling pathways, and an endogenous protection factor from redox stress and inflammation, and it helps against diseases of the advanced age and might improve performance in athletes. Evaluations to assess its potential as an antibacterial agent, as well as its use in anti-inflammatory, antioxidant, and neurologic nanotechnology applications is ongoing. On the other hand, the knowledge on its pathomolecular mechanism involved in brain damage in Crigler–Najjar syndrome and in neonatal hyperbilirubinemia is expanding. The golden standard therapy (phototherapy) seems inefficient in pre-term neonates, and severe hyperbilirubinemia persists as a major cause of neonatal death in different parts of the world, requiring commitment to develop innovative studies and therapeutic approaches.
Therefore, advancing the understanding on the molecular functions of this pigment and of the enzymes involved in its metabolism (the yellow players) and biological function is crucial and is not only a never ending need for human health but also a new challenge for its technological uses.
Papers aimed at exploring these aspects of the yellow players are welcome.
Dr. Silvia Gazzin
Guest Editor
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Keywords
- bilirubin
- biomedical science
- neurobiology
- Parkinson’s disease
- brain neuroprotection
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