Molecular Biology of Sulfatase
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (29 April 2024) | Viewed by 751
Special Issue Editor
Interests: role of sulfatases and sulfotransferases in human diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The impact of sulfation on biological processes has been of interest for decades, particularly with regard to the inherited deficiency of sulfatases in the mucopolysaccharidoses; these include MPS VI (Maroteaux-Lamy Syndrome), in which there is a deficiency of N-acetylgalactosamine-4-sulfatase, and MPS IVA, in which there is a deficiency of N-acetylgalactosamine-6-sulfatase (Morquio Syndrome). Recently, attention has been directed to the molecular consequences of an acquired decline in sulfatase activity due to changes in the cellular microenvironment. Identification of the roles of sulfatases and sulfotransferase enzymes in signaling, transcription, and cell differentiation has focused on the mechanisms of action of specific enzymes in well-defined biological systems. Together, sulfatases and sulfotransferase confer remarkable specificity in the regulation of vital processes in plants, microbiota, and macrobiota. Via the post-translational modification of carbohydrates, including glycosaminoglycans, lipids, proteins, and steroids, sulfation confers precise interactions within and between cells and in response to the extracellular environment. In this collection of articles, the range of effects of sulfation and of sulfatase and sulfotransferase activity on pathobiology will be examined. This increased focus on the role of sulfation in signalling and the regulation of vital cell functions, including proliferation, differentiation, and transcription, may provide novel insights into basic metabolic and molecular pathways and offer new targets able to improve human health.
Dr. Joanne Tobacman
Guest Editor
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Keywords
- chondroitin sulfatases
- sulfotransferases
- steroid, tyrosine, and other sulfatases
- metabolic pathways affected by sulfation
- impact of changes in sulfation on disease
