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Advances in Heart Diseases: Molecular Pathogenesis, Biomarkers and Therapies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 1808

Special Issue Editor


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Guest Editor
Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy
Interests: biomarkers; heart failure; ischemic heart disease; preserved ejection fraction; cardiology; fibrosis; inflammation; non-coding RNA
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, significant advancements have been achieved in the diagnosis and management of heart diseases, along with an enhanced understanding of their molecular pathogenesis. These developments have been instrumental in leveraging specific biomarkers to guide increasingly innovative therapeutic interventions. Novel insights into the molecular pathways implicated in disease progression have emerged.

Concurrently, the identification and validation of biomarkers have transformed diagnostic and prognostic approaches, facilitating early detection, streamlined management, and personalized treatment strategies. Biomarkers such as troponins, BNPs, and non-coding RNAs have emerged as invaluable tools in clinical practice, furnishing clinicians with crucial information for patient management. Moreover, therapeutic interventions have undergone substantial evolution, encompassing traditional cardiac pharmacological agents alongside novel pharmacological and interventional therapies, as well as comorbidity treatments, aimed at alleviating disease burden and enhancing patient outcomes.

In this Special Issue, we will explore the strides in molecular understanding, biomarker discovery, and therapeutic innovation, promising a brighter future in the battle against heart disease.

Dr. Nadia Aspromonte
Guest Editor

Manuscript Submission Information

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Keywords

  • heart diseases
  • biomarkers
  • molecular pathways
  • personalized medicine
  • interventional therapies

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Published Papers (1 paper)

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Review

15 pages, 940 KiB  
Review
Microvascular Dysfunction across the Spectrum of Heart Failure Pathology: Pathophysiology, Clinical Features and Therapeutic Implications
by Giulia La Vecchia, Isabella Fumarulo, Andrea Caffè, Mario Chiatto, Rocco A. Montone and Nadia Aspromonte
Int. J. Mol. Sci. 2024, 25(14), 7628; https://doi.org/10.3390/ijms25147628 - 11 Jul 2024
Cited by 1 | Viewed by 1553
Abstract
Coronary microvascular dysfunction (CMD) plays a crucial role across the spectrum of heart failure (HF) pathology, contributing to disease development, progression, and outcomes. The pathophysiological mechanisms linking CMD to HF are complex and still not completely understood and include chronic inflammation, oxidative stress, [...] Read more.
Coronary microvascular dysfunction (CMD) plays a crucial role across the spectrum of heart failure (HF) pathology, contributing to disease development, progression, and outcomes. The pathophysiological mechanisms linking CMD to HF are complex and still not completely understood and include chronic inflammation, oxidative stress, and neurohormonal activation. Despite the diagnostic and prognostic relevance in patients with HF, there is no specific therapeutic strategy targeting CMD to date. Moreover, the diagnosis of this clinical condition is challenging. In this review article, we aim to discuss the different clinical pathogenetic mechanisms linking CMD to HF across the different spectra of these diseases, their prognostic relevance, and the possible therapeutic targets along with the remaining knowledge gaps in the field. Full article
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