Diverse Functional Roles of Fibrinogen and Fibrin in Mechanisms of Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 1991
Special Issue Editor
Interests: intracellular bacteria; endothelium; infection; pathogenesis; host-pathogen interaction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Since its discovery over three centuries ago, studies on fibrin(ogen) have led to remarkable advances in structure–function analysis and evidence for the involvement of this versatile biological molecule in multiple physiological and pathological scenarios, including cardiovascular ailments, inflammation, infection, tumor growth and metastasis, and neurological disorders. Interactions of fibrin(ogen) with plasma proteins and receptors on the platelets, leukocytes, endothelial cells and other cells regulate a multitude of signaling pathways and their downstream consequences. Alterations in the levels and/or functions of fibrin(ogen) increase the risk of hemorrhage, thrombosis, infection, inflammation and many other disease states. Genetic and pharmacologic approaches have further ascertained the important contributions of fibrinogen during local or systemic inflammation. A collection of cellular and molecular analyses further project fibrin(ogen) as a signaling molecule determining the balance between hemostasis and thrombosis, coagulation and fibrosis, and eventually life and death. Continued efforts to enhance our understanding of the roles of fibrin(ogen) in these processes are likely to advance treatment options and the prevention of many human diseases.
This Special Issue invites original research, mini/full reviews and perspectives focused on all aspects of fibrin(ogen), and aims to provide a comprehensive summary of ongoing biomedical research on the roles of fibrin(ogen) in thrombosis, hemostasis and other diseases.
Dr. Abha Sahni
Guest Editor
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Keywords
- fibrinogen
- fibrin
- endothelium
- thrombosis
- hemostasis
- infection
- cancer
- inflammation
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