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New Insights into Aquaporins: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 749

Special Issue Editors


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Guest Editor
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal
Interests: aquaporin; inflammation; immunology; metabolic diseases
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Special Issue Information

Dear Colleagues,

Aquaporins (AQPs) are involved in many biological functions, including transepithelial fluid transport, cell migration and proliferation, brain edema and neuroexcitation, adipocyte metabolism, and epidermal water retention. In the plant kingdom, aquaporins are key proteins providing strict regulation of water uptake and transport across cellular membranes and tissues at the whole-plant level, regulating plant growth and development. Over the last decade, aquaporins have become a hot area of research in molecular cell biology, biochemistry, and biophysics, with increasing physiological and medical implications. In addition, human diseases caused by aquaporin dysfunction have unveiled these proteins’ potential as drug targets and opened new perspectives with which to untangle mechanisms of disease.

This Special Issue aims to provide an updated scientific view of the aquaporin field, including structure–function relationships, physiological and chemical regulation, implications in disease, and potential as drug targets, creating opportunities for drug development and novel therapies. Authors are invited to submit original research and review papers addressing these topics for this Special Issue.

Dr. Graça Soveral
Dr. Inês Vieira Da Silva
Guest Editors

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Keywords

  • aquaporin
  • membrane channel
  • regulation
  • pathophysiology
  • drug target

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Published Papers (1 paper)

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Research

15 pages, 2866 KiB  
Article
Glycerol Handling in Paired Visceral and Subcutaneous Adipose Tissues in Women with Normal Weight and Upper-Body Obesity
by Anne Nørholm, Ida Guldbrandt Kjær, Esben Søndergaard, Birgitte Nellemann, Søren Nielsen and Janne Lebeck
Int. J. Mol. Sci. 2024, 25(16), 9008; https://doi.org/10.3390/ijms25169008 - 19 Aug 2024
Viewed by 595
Abstract
In adipose tissue, reduced expression of the glycerol channel aquaporin 7 (AQP7) has been associated with increased accumulation of triglyceride. The present study determines the relative protein abundances of lipolytic enzymes, AQP7, and cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in paired mesenteric and omental visceral [...] Read more.
In adipose tissue, reduced expression of the glycerol channel aquaporin 7 (AQP7) has been associated with increased accumulation of triglyceride. The present study determines the relative protein abundances of lipolytic enzymes, AQP7, and cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in paired mesenteric and omental visceral adipose tissue (VAT) and abdominal and femoral subcutaneous adipose tissue (SAT) in women with either normal weight or upper-body obesity. No differences in the expression of hormone-sensitive lipase (HSL) or AQP7 were found between the two groups in the four depots. The expression of adipocyte triglyceride lipase (ATGL) and HSL were higher in omental VAT and femoral SAT than in mesenteric VAT in both groups of women. Similarly, AQP7 expression was higher in omental VAT than in mesenteric VAT. The expression of PEPCK-C was lower in omental VAT than in femoral SAT. No correlation between the expression of AQP7 and the mean adipocyte size was observed; however, the expression of PEPCK-C positively correlated with the mean adipocyte size. In conclusion, a depot-specific protein expression pattern was found for ATGL, HSL, AQP7, and PEPCK-C. The expression pattern supports that the regulation of AQP7 protein expression is at least in part linked to the lipolytic rate. Furthermore, the results support that the synthesis of glycerol-3-phosphate via glyceroneogenesis contributes to regulating triglyceride accumulation in white adipose tissue in women. Full article
(This article belongs to the Special Issue New Insights into Aquaporins: 2nd Edition)
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